4.7 Article

A dual-channel optogenetic stimulator selectively modulates distinct defensive behaviors

期刊

ISCIENCE
卷 25, 期 1, 页码 -

出版社

CELL PRESS
DOI: 10.1016/j.isci.2021.103681

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资金

  1. National Key R&D Program of China [2021ZD0203900]
  2. Science and Technology Innovation Commission of Shenzhen [JCYJ20170411140807570]
  3. CAS Key Laboratory of Brain Connectome and Manipulation [2019DP173024, KFKT2020006]
  4. National Natural Science Foundation of China (NSFC) [61874064]
  5. Beijing Municipal Natural Science Foundation [4202032]
  6. Beijing Innovation Center for Future Chips at Tsinghua University
  7. Beijing National Research Center For Information Science And Technology [BNR2019ZS01005]

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Researchers have developed a wireless optoelectronic system for studying superior colliculus (SC), a structure related to defensive behaviors, in rodents using functional optogenetics.
Implantable devices and systems have been emerging as powerful tools for neuroscience research and medical applications. Here we report a wireless, dual-channel optoelectronic system for functional optogenetic interrogation of superior colliculus (SC), a layered structure pertinent to defensive behaviors, in rodents. Specifically, a flexible and injectable probe comprises two thin-film microscale light-emitting diodes (micro-LEDs) at different depths, providing spatially resolved optical illuminations within the tissue. Under remote control, these micro-LEDs interrogate the intermediate layer and the deep layer of the SC (ILSC and DLSC) of the same mice, and deterministically evoke distinct freezing and flight behaviors, respectively. Furthermore, the system allows synchronized optical stimulations in both regions, and we discover that the flight response dominates animals' behaviors in our experiments. In addition, c-Fos immunostaining results further elucidate the functional hierarchy of the SC. These demonstrations provide a viable route to unraveling complex brain structures and functions.

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