Ants detect cancer cells through volatile organic compounds

Cancer is among the world's leading causes of death. A critical challenge for public health is to develop a noninvasive, inexpensive, and efficient tool for early cancer detection. Cancer cells are characterized by an altered metabolism, producing unique patterns of volatile organic compounds (VOCs) that can be used as cancer biomarkers. Dogs can detect VOCs via olfactory associative learning, but training dogs is costly and time-consuming. Insects, such as ants, have a refined sense of smell and can be rapidly trained. We show that individual ants need only a few training trials to learn, memorize, and reliably detect the odor of human cancer cells. These performances rely on specific VOC patterns, as shown by gas chromatography/mass spectrometry. Our findings suggest that using ants as living tools to d-test biomarkers of human cancer is feasible, fast, and less laborious than using other animals.

Automated summary

Cancer is a leading cause of death worldwide. This study demonstrates that ants can be trained to detect the odor of human cancer cells, providing a noninvasive and efficient method for early cancer detection.