4.6 Article

SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear

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Summary: A multiscale computational model is developed to recreate shear-induced platelet aggregation (SIPA) in silico, showing good agreement with in vitro observations in terms of capture time and morphology of platelet aggregates. The model reveals that the capture of aggregates can occur within milliseconds, providing insights into the biophysical mechanisms of SIPA that are difficult to access with single-molecule measurements.

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