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Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma
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Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
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Invariant phenotype and molecular association of biallelic TET2 mutant myeloid neoplasia
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TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells
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5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia
Jae-Sook Ahn et al.
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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
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Distinct roles for TET family proteins in regulating human erythropoiesis
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TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood
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Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
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Acute loss of TET function results in aggressive myeloid cancer in mice
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Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence
Cheng Li et al.
CELL REPORTS (2015)
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
Zhigang Zhao et al.
CELL REPORTS (2015)
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
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Characterization of acute myeloid leukemia based on levels of global hydroxymethylation
Leonie I. Kroeze et al.
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The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
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Age-related mutations associated with clonal hematopoietic expansion and malignancies
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Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
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NEW ENGLAND JOURNAL OF MEDICINE (2014)
Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development
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DEVELOPMENTAL CELL (2013)
TET enzymes, TDG and the dynamics of DNA demethylation
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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
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The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
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Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA
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Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
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Mutation in TET2 in Myeloid Cancers
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NEW ENGLAND JOURNAL OF MEDICINE (2009)