4.6 Article

The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression

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Summary: The cell wall integrity (CWI) signaling pathway plays a role in both cell wall biogenesis and the response to genotoxic stress. When activated by DNA damaging agents, the protein kinase Mpk1 is able to initiate a response through an intracellular mechanism that does not involve the CWI pathway. Additionally, the protein kinase C (Pkc1), a key kinase in the CWI signaling cascade, is also involved in the response to genotoxic stress independently of its role in activating Mpk1.

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