4.6 Article

COVID-19-Associated Pulmonary Aspergillosis in a Tertiary Hospital

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients-a multinational observational study by the European Confederation of Medical Mycology

Juergen Prattes et al.

Summary: Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a common complication among critically ill COVID-19 patients in ICU. It is more prevalent in older patients, those receiving invasive ventilation, and those receiving tocilizumab treatment. CAPA is an independent predictor of ICU mortality.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

Article Immunology

Tocilizumab for Treatment of Mechanically Ventilated Patients With COVID-19

Emily C. Somers et al.

Summary: In mechanically ventilated COVID-19 patients, the use of IL-6 blockade with tocilizumab was associated with lower mortality despite higher occurrence of superinfections.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study

Michele Bartoletti et al.

Summary: The study showed a high incidence of CAPA among critically ill COVID-19 patients, and its occurrence seems to alter the natural course of the disease.

CLINICAL INFECTIOUS DISEASES (2021)

Letter Respiratory System

Can SARS-CoV-2 be a Risk Factor for Pulmonary Aspergillosis?

Marta Garcia Clemente et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2021)

Editorial Material Respiratory System

Influenza, SARS-CoV-2 and Invasive Pulmonary Aspergillosis

Marta Garcia Clemente et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2021)

Article Immunology

Performance of the Bronchoalveolar Lavage Fluid Aspergillus Galactomannan Lateral Flow Assay With Cube Reader for Diagnosis of Invasive Pulmonary Aspergillosis: A Multicenter Cohort Study

Jeffrey D. Jenks et al.

Summary: The study demonstrated that the Aspergillus Galactomannan Lateral Flow Assay showed good diagnostic performance for invasive aspergillosis, and its performance was consistent across different patient cohorts and centers.

CLINICAL INFECTIOUS DISEASES (2021)

Editorial Material Immunology

Invasive Fungal Disease Complicating Coronavirus Disease 2019: When It Rains, It Spores

Martin Hoenigl

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

A National Strategy to Diagnose Coronavirus Disease 2019-Associated Invasive Fungal Disease in the Intensive Care Unit

P. Lewis White et al.

Summary: Invasive fungal disease is common in critically ill COVID-19 patients, with 26.7% incidence rate including 14.1% aspergillosis and 12.6% yeast infections. Mortality rates are reduced with antifungal therapy, while corticosteroid use and history of chronic respiratory disease increase the likelihood of aspergillosis. Strategic diagnostic screening and antifungal prophylaxis may enhance the management of COVID-19 patients.

CLINICAL INFECTIOUS DISEASES (2021)

Article Dermatology

Bronchoscopy safety precautions for diagnosing COVID-19 associated pulmonary aspergillosis-A simulation study

Philipp Koehler et al.

Summary: Through simulation experiments, it was found that there is extensive aerosol generation, droplet spread, and surface contamination during bronchoscopy. By repurposing covers for ultrasound transducers or endoscopic cameras to seal the tube opening during bronchoscopy in mechanically ventilated patients, exposure of health-care workers and surface contamination can be efficiently reduced.

MYCOSES (2021)

Article Critical Care Medicine

Occurrence of Invasive Pulmonary Fungal Infections in Patients with Severe COVID-19 Admitted to the ICU

Arnaud Fekkar et al.

Summary: This study examined the occurrence of invasive fungal respiratory superinfections in severe COVID-19 patients admitted to five ICUs in France, finding that patients with no underlying immunosuppression seem at low risk of invasive fungal secondary infection.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Infectious Diseases

Risk factors associated with COVID-19-associated pulmonary aspergillosis in ICU patients: a French multicentric retrospective cohort

Sarah Delliere et al.

Summary: Invasive pulmonary aspergillosis (IPA) is a relatively common complication in severe COVID-19 patients, leading to increased mortality. Treatment with azithromycin for >= 3 days is associated with higher risk of developing probable IPA, while high-dose dexamethasone may also play a role in IPA occurrence.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Dermatology

Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia

Gonzalo Segrelles-Calvo et al.

Summary: As the COVID-19 pandemic continues to spread globally, the risk of invasive fungal infections as a coinfection poses a significant threat to severely ill patients. Larger cohort studies are necessary to investigate the impact of COVID-19 immunosuppressive therapy on the development of aspergillosis.

MYCOSES (2021)

Review Dermatology

Invasive pulmonary aspergillosis in the COVID-19 era: An expected new entity

Marina Machado et al.

Summary: COVID-19-associated pulmonary aspergillosis is a serious and potentially life-threatening complication in severe COVID-19 patients, especially those receiving corticosteroids. Mortality rate in reviewed cases is high at 56.3%.

MYCOSES (2021)

Letter Infectious Diseases

Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis reply

Kauser Jabeen et al.

LANCET INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis

Kauser Jabeen et al.

LANCET INFECTIOUS DISEASES (2021)

Article Dermatology

COVID-19-associated pulmonary aspergillosis: a prospective single-center dual case series

Eelco F. J. Meijer et al.

Summary: CAPA has emerged as an invasive fungal disease affecting previously immunocompetent, mechanically ventilated ICU patients with high mortality. This study found a significant decrease in the number of COVID-19 patients needing mechanical ventilation in the ICU during the second wave, but a slightly higher percentage were diagnosed with CAPA. The use of dexamethasone did not show significant impact on CAPA incidence or mortality rates.

MYCOSES (2021)

Review Immunology

Navigating the Uncertainties of COVID-19-Associated Aspergillosis: A Comparison With Influenza-Associated Aspergillosis

Frederic Lamoth et al.

Summary: Invasive pulmonary aspergillosis is increasingly recognized as a life-threatening complication of severe respiratory viral infections, such as influenza, and concerns have been raised about its potential complicating COVID-19 in ICU patients. Differences in diagnostic strategies, definitions, and local factors may contribute to the variable incidence of this complication. The distinction between COVID-19-associated pulmonary aspergillosis (CAPA) and influenza-associated pulmonary aspergillosis (IAPA) lies in the majority of CAPA cases being classified as putative rather than proven/probable IPA, and the discrepancies can possibly be explained by the distinct physiopathology of influenza and COVID-19.

JOURNAL OF INFECTIOUS DISEASES (2021)

Review Dermatology

Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches

Jeffrey D. Jenks et al.

Summary: This review focuses on the epidemiology, definitions, diagnostic tests, clinical presentation, and imaging findings of invasive aspergillosis (IA) in critically ill patients in the intensive care unit, providing direction for further research.

MYCOSES (2021)

Letter Critical Care Medicine

COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges

Juergen Prattes et al.

INTENSIVE CARE MEDICINE (2021)

Article Microbiology

Aspergillus Test Profiles and Mortality in Critically Ill COVID-19 Patients

Mehmet Ergun et al.

Summary: Literature on COVID-19-associated pulmonary aspergillosis has conflicting observations, with some CAPA patients surviving without antifungal therapy and discrepancies between CAPA diagnosis and autopsy findings. A case-control study was conducted comparing Aspergillus test profiles in CAPA patients and controls. The study showed that positive serum GM and BDG were associated with increased mortality in CAPA patients, highlighting the need for biomarkers to differentiate between respiratory tract colonization and tissue-invasive CAPA disease.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

Review Medicine, General & Internal

Aspergillus in Critically Ill COVID-19 Patients: A Scoping Review

Erlangga Yusuf et al.

Summary: Several studies have reported varying proportions of Aspergillus findings in COVID-19 patients, with most studies not explicitly mentioning radiographic findings. Respiratory samples were usually obtained to investigate clinical deterioration, with a range of testing methods such as culture, antigen, or PCR used.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Immunology

COVID-19-Associated Pulmonary Aspergillosis, March-August 2020

Jon Salmanton-Garcia et al.

Summary: This study found that most patients with coronavirus disease-associated pulmonary aspergillosis (CAPA) are diagnosed shortly after admission, with the majority being treated in the ICU. Azole-resistant strains of Aspergillus fumigatus were common in patients, and voriconazole was the main treatment choice. The overall mortality rate was approximately 52.2%, with about one third of deaths attributed to CAPA.

EMERGING INFECTIOUS DISEASES (2021)

Article Immunology

Aspergillosis Complicating Severe Coronavirus Disease

Kieren A. Marr et al.

Summary: The syndromes of pulmonary aspergillosis complicating severe viral infections are distinct from classic invasive aspergillosis, which is recognized most frequently in persons with neutropenia and in other immunocompromised persons.

EMERGING INFECTIOUS DISEASES (2021)

Letter Respiratory System

Invasive Aspergillosis as a Complication of Influenza Virus H3N2 Infection

Marta Garcia Clemente et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2020)

Article Infectious Diseases

High -volume culture and quantitative real-time PCR for the detection of Aspergillus in sputum

P. Vergidis et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

Letter Critical Care Medicine

COVID-19-associated Pulmonary Aspergillosis

Andreas L. E. van Arkel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Virology

Coronavirus disease 2019: What we know?

Feng He et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Letter Critical Care Medicine

Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19

Alexandre Alanio et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Dermatology

COVID-19 associated pulmonary aspergillosis

Philipp Koehler et al.

MYCOSES (2020)

Article Immunology

Invasive Aspergillosis as an Under-recognized Superinfection in COVID-19

George R. Thompson et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

Review Microbiology

COVID-19 Associated Pulmonary Aspergillosis (CAPA)-From Immunology to Treatment

Amir Arastehfar et al.

JOURNAL OF FUNGI (2020)

Letter Medicine, General & Internal

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Catherine F. Houlihan et al.

LANCET (2020)

Article Critical Care Medicine

Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study

Alexander F. A. D. Schauwvlieghe et al.

LANCET RESPIRATORY MEDICINE (2018)

Letter Critical Care Medicine

Influenza-associated Aspergillosis in Critically III Patients

Frank L. van de Veerdonk et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Article Respiratory System

Influenza virus-induced lung injury: pathogenesis and implications for treatment

Susanne Herold et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Editorial Material Immunology

Invasive Aspergillosis Complicating Pandemic Influenza A (H1N1) Infection in Severely Immunocompromised Patients

Carolina Garcia-Vidal et al.

CLINICAL INFECTIOUS DISEASES (2011)

Article Critical Care Medicine

Host adaptive immunity deficiency in severe pandemic influenza

Jesus F. Bermejo-Martin et al.

CRITICAL CARE (2010)

Article Infectious Diseases

Invasive aspergillosis in glucocorticoid-treated patients

Russell E. Lewis et al.

MEDICAL MYCOLOGY (2009)