期刊
BIOMEDICINES
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10020486
关键词
nanocarriers; functionalized liposomes; albumin-based nanosystems; poorly water-soluble drugs; targeted cancer therapy
资金
- Fundacao para a Ciencia e a Tecnologia (FCT-Portugal) [UIDB/04650/2020, UIDB/00686/2020]
- FEDER/FCT [PTDC/MED-ONC/31354/2017]
- FCT
- FSE (Fundo Social Europeu) through Programa Operacional Regional Norte [2020.04975.BD]
- Fundação para a Ciência e a Tecnologia [PTDC/MED-ONC/31354/2017, 2020.04975.BD, UIDB/04650/2020, UIDB/00686/2020] Funding Source: FCT
Cancer is a major cause of death worldwide. To overcome the problems associated with chemotherapy, the scientific community has developed functionalized nanosystems to deliver drugs to cancer cells, targeting overexpressed receptors, proteins, and organelles. This review focuses on the recent developments of liposomes and albumin-based nanosystems as carriers for poorly water-soluble drugs.
Cancer is one of the leading causes of death worldwide. In the available treatments, chemotherapy is one of the most used, but has several associated problems, namely the high toxicity to normal cells and the resistance acquired by cancer cells to the therapeutic agents. The scientific community has been battling against this disease, developing new strategies and new potential chemotherapeutic agents. However, new drugs often exhibit poor solubility in water, which led researchers to develop functionalized nanosystems to carry and, specifically deliver, the drugs to cancer cells, targeting overexpressed receptors, proteins, and organelles. Thus, this review is focused on the recent developments of functionalized nanosystems used to carry poorly water-soluble drugs, with special emphasis on liposomes and albumin-based nanosystems, two major classes of organic nanocarriers with formulations already approved by the U.S. Food and Drug Administration (FDA) for cancer therapeutics.
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