4.7 Review

Potential Roles of Sestrin2 in Alzheimer's Disease: Antioxidation, Autophagy Promotion, and Beyond

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Upregulation Sestrin2 protects against hydrogen peroxide-induced oxidative damage bovine mammary epithelial cells via a Keap1-Nrf2/ARE pathway

Mengjiao Chen et al.

Summary: SESN2, a conservative oxidative stress protein, plays a crucial role in regulating energy metabolism, cell proliferation, apoptosis, and mitochondria autophagy. Knockout of SESN2 exacerbates apoptosis and oxidative damage, while its overexpression decreases apoptosis and blocks oxidative damage in MAC-T cells treated with H2O2. Additionally, SESN2 can alleviate oxidative stress and cell apoptosis by activating the Keap1-Nrf2/ARE pathway in H2O2-treated MAC-T cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Neurosciences

Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of Keap1

Fang Yang et al.

Summary: The study demonstrates that Sesn1 exerts neuroprotective effects on neurons following cerebral ischemia/reperfusion injury by potentiating Nrf2 activation to ameliorate OGD/R-induced damage.

BRAIN RESEARCH (2021)

Article Endocrinology & Metabolism

Decreased Sestrin levels in patients with type 2 diabetes and dyslipidemia and their association with the severity of atherogenic index

S. Sundararajan et al.

Summary: The study revealed that Sestrin2 levels are significantly decreased in diabetes and dyslipidemia, showing a strong association with atherogenic risk factors and atherogenic index severity. This suggests that Sestrin2 may serve as a biomarker for assessing atherogenesis.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

Review Biology

Tau Oligomers Neurotoxicity

Grazyna Niewiadomska et al.

Summary: Tau oligomers (TauOs) formed during the early stages of tau aggregation play a key role in triggering neuronal loss and behavioral impairments in tauopathies like Alzheimer's disease.

LIFE-BASEL (2021)

Review Biochemistry & Molecular Biology

Sestrin 2, a potential star of antioxidant stress in cardiovascular diseases

Yunxia Liu et al.

Summary: This review discusses the impact of Sestrin 2 on redox signaling and its role in various cardiovascular diseases. The authors speculate that Sestrin 2 may play an important role in cardiovascular diseases by stimulating antioxidation processes and promoting cell adaptation to stress conditions and the environment, suggesting potential therapeutic strategies.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Cell Biology

GSK-3 and Tau: A Key Duet in Alzheimer's Disease

Carmen Laura Sayas et al.

Summary: GSK-3 is a crucial player in AD pathology, contributing to the hyperphosphorylation of tau protein and involvement in various neuronal processes that are dysregulated during AD pathogenesis. Targeting GSK-3 or GSK-3-phosphorylated tau could hold potential for developing AD therapies.
Article Biochemistry & Molecular Biology

The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons

Yi-Heng Hsieh et al.

Summary: Senile plaques composed of neurotoxic amyloid-beta peptide are a pathological hallmark of Alzheimer's disease. Sestrin2, induced by various stressors, promotes autophagy and exerts antioxidative effects. The molecular mechanisms underlying A beta induction of sestrin2 involve the transcription factors p53 and NF-kappa B.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Biochemistry & Molecular Biology

Neuronal Trafficking of the Amyloid Precursor Protein-What Do We Really Know?

Tong Lin et al.

Summary: Alzheimer's disease is a common neurodegenerative disease that primarily affects memory and cognitive abilities, with no known cure. Early diagnosis and understanding of its pathology are crucial for effective management of the disease.

BIOMEDICINES (2021)

Article Clinical Neurology

Implication of sestrin3 in epilepsy and its comorbidities

Francesca Lovisari et al.

Summary: The study revealed that SESN3 knockout rats demonstrated a significant delay in status epilepticus onset compared to control rats, suggesting a potential role of SESN3 in the occurrence and severity of seizures. Additionally, SESN3 knockout rats displayed less anxiety in behavioral tests compared to control rats.

BRAIN COMMUNICATIONS (2021)

Article Clinical Neurology

2021 Alzheimer's disease facts and figures

[Anonymous]

Summary: Alzheimer's disease has a significant impact on individuals and society as a whole, with a large number of patients in the United States and a potential for continued growth in the future. The value of unpaid caregivers has increased despite a decline in their numbers, and healthcare costs are on the rise. Racial and ethnic disparities in healthcare persist, highlighting the need for greater diversity in dementia care workforce and clinical trials.

ALZHEIMERS & DEMENTIA (2021)

Article Geriatrics & Gerontology

Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease

Nitish Rai et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

Review Pharmacology & Pharmacy

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

Sona Vodenkova et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Review Pharmacology & Pharmacy

Next-generation drug repurposing using human genetics and network biology

Serguei Nabirotchkin et al.

CURRENT OPINION IN PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Alzheimer's disease: phenotypic approaches using disease models and the targeting of tau protein

Elisabetta Lauretti et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

Review Neurosciences

Drug Repositioning for Alzheimer's Disease: Finding Hidden Clues in Old Drugs

Masafumi Ihara et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

Article Biochemistry & Molecular Biology

Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway

Xue Han et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Roles of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron

A-Ching Chao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Article Medicine, Research & Experimental

Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2

Seunghyeong Lee et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Nanoscience & Nanotechnology

Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer

Elaheh Entezar-Almahdi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Clinical Neurology

Drug repositioning and repurposing for Alzheimer disease

Clive Ballard et al.

NATURE REVIEWS NEUROLOGY (2020)

Article Cell Biology

Sestrin family - the stem controlling healthy ageing

Alexander Haidurov et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

Review Cell Biology

Clinical trials of new drugs for Alzheimer disease

Li-Kai Huang et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

Article Biochemistry & Molecular Biology

Pentamethylquercetin protects against cardiac remodeling via activation of Sestrin2

Jing-Xia Du et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Stefano Thellung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Chemistry, Medicinal

Health benefits of resveratrol: Evidence from clinical studies

Akhand Pratap Singh et al.

MEDICINAL RESEARCH REVIEWS (2019)

Review Nutrition & Dietetics

Influence of Resveratrol on the Immune Response

Lucia Malaguarnera

NUTRIENTS (2019)

Review Medicine, General & Internal

Emerging Roles of Sestrins in Neurodegenerative Diseases: Counteracting Oxidative Stress and Beyond

Shang-Der Chen et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Neurosciences

The neuropathological diagnosis of Alzheimer's disease

Michael A. DeTure et al.

MOLECULAR NEURODEGENERATION (2019)

Review Clinical Neurology

Ageing as a risk factor for neurodegenerative disease

Yujun Hou et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Immunology

Eupatilin protects chondrocytes from apoptosis via activating sestrin2-dependent autophagy

Yiting Lou et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

UniProt: a worldwide hub of protein knowledge

Alex Bateman et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Biochemistry & Molecular Biology

Health benefits of resveratrol administration

Sabina Galiniak et al.

ACTA BIOCHIMICA POLONICA (2019)

Review Materials Science, Biomaterials

Fundamentals of cross-seeding of amyloid proteins: an introduction

Baiping Ren et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Review Clinical Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack et al.

ALZHEIMERS & DEMENTIA (2018)

Review Biochemistry & Molecular Biology

Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome

Xu-Qiao Chen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Chemistry, Medicinal

5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells

Kyuhwa Seo et al.

ARCHIVES OF PHARMACAL RESEARCH (2017)

Review Clinical Neurology

Emerging treatments for Alzheimer's disease for non-amyloid and non-tau targets

Ayesha Khan et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

Review Biochemistry & Molecular Biology

More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy

Shang-Der Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Cell Biology

Pathology of Neurodegenerative Diseases

Brittany N. Dugger et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Review Clinical Neurology

Emerging treatments for Alzheimer's disease for non-amyloid and non-tau targets

Ayesha Khan et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

Article Neurosciences

Alzheimer's Disease and the Amyloid-β Peptide

M. Paul Murphy et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Biochemistry & Molecular Biology

Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury

Kyung Hwan Jegal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Review Neurosciences

Melatonin: Pharmacology, Functions and Therapeutic Benefits

Sylvie Tordjman et al.

CURRENT NEUROPHARMACOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Stroke Risk Factors, Genetics, and Prevention

Amelia K. Boehme et al.

CIRCULATION RESEARCH (2017)

Article Neurosciences

Oxidative Stress in Neurodegenerative Diseases

Ewa Niedzielska et al.

MOLECULAR NEUROBIOLOGY (2016)

Article Multidisciplinary Sciences

METABOLISM Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Robert A. Saxton et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

METABOLISM Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson et al.

SCIENCE (2016)

Article Biochemistry & Molecular Biology

Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress

Kyung Hwan Jegal et al.

APOPTOSIS (2016)

Letter Cardiac & Cardiovascular Systems

Sestrin family may play important roles in the regulation of cardiac pathophysiology

Hai-Han Liao et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Review Clinical Neurology

Review: Sporadic Parkinson's disease: development and distribution of -synuclein pathology

K. Del Tredici et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2016)

Article Cell Biology

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Jiangbin Ye et al.

GENES & DEVELOPMENT (2015)

Article Medicine, General & Internal

Parkinson's disease

Lorraine V. Kalia et al.

LANCET (2015)

Article Biochemistry & Molecular Biology

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

Yi-Sheng Hou et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

Michael R. Johnson et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Hanseong Kim et al.

NATURE COMMUNICATIONS (2015)

Article Neurosciences

Synaptic activity and Alzheimer's disease: a critical update

Davide Tampellini

FRONTIERS IN NEUROSCIENCE (2015)

Review Neurosciences

Methylglyoxal, the dark side of glycolysis

Igor Allaman et al.

FRONTIERS IN NEUROSCIENCE (2015)

Review Neurosciences

The Pathophysiology of Axonal Transport in Alzheimer's Disease

Elena Vicario-Orri et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Biochemistry & Molecular Biology

NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons

M. -F. Wu et al.

FREE RADICAL RESEARCH (2014)

Article Clinical Neurology

Function and Dysfunction of Presenilin

Jie Shen

NEURODEGENERATIVE DISEASES (2014)

Article Pharmacology & Pharmacy

Resveratrol attenuates methylglyoxal-induced mitochondrial dysfunction and apoptosis by Sestrin2 induction

Kyuhwa Seo et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes

Ji Hye Yang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Multidisciplinary Sciences

Hepatoprotective role of Sestrin2 against chronic ER stress

Hwan-Woo Park et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

Daniele Del Rio et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Cell Biology

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

Jun Hee Lee et al.

CELL METABOLISM (2013)

Review Neurosciences

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

Zaira Esposito et al.

CNS NEUROSCIENCE & THERAPEUTICS (2013)

Review Biochemistry & Molecular Biology

PGC-1α, mitochondrial dysfunction, and Huntington's disease

Ashu Johri et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Review Neurosciences

Impaired Transcription in Alzheimer's Disease: Key Role in Mitochondrial Dysfunction and Oxidative Stress

Gladys L. Caldeira et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Article Biochemistry & Molecular Biology

Upregulation of Sestrin-2 Expression via P53 Protects Against 1-Methyl-4-Phenylpyridinium (MPP plus ) Neurotoxicity

Zhou Daixing et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

Article Pharmacology & Pharmacy

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction

So Hee Jin et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Article Cell Biology

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

Jun Hee Lee et al.

CELL METABOLISM (2012)

Review Biochemistry & Molecular Biology

Ageing as a Risk Factor for Disease

Teresa Niccoli et al.

CURRENT BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Nrf2-ARE pathway regulates induction of Sestrin-2 expression

Bo Yeon Shin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Neurosciences

Antioxidant Sestrin-2 Redistribution to Neuronal Soma in Human Immunodeficiency Virus-Associated Neurocognitive Disorders

Virawudh Soontornniyomkij et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2012)

Article Physiology

Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction

Nels Olson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)

Review Neurosciences

Amyloid Precursor Protein Processing and Alzheimer's Disease

Richard J. O'Brien et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Review Cell Biology

Ageing and neurodegenerative diseases

Chia-Wei Hung et al.

AGEING RESEARCH REVIEWS (2010)

Article Cell Biology

Sestrins at the crossroad between stress and aging

Jun Hee Lee et al.

AGING-US (2010)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

Goekhan S. Hotamisligil

Review Medicine, Research & Experimental

Stressin' Sestrins take an aging fight

Andrei V. Budanou et al.

EMBO MOLECULAR MEDICINE (2010)

Article Neurosciences

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

Albert Y. Sun et al.

MOLECULAR NEUROBIOLOGY (2010)

Article Neurosciences

Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway

Kun-Lin Chen et al.

NEUROBIOLOGY OF DISEASE (2010)

Article Multidisciplinary Sciences

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

Jun Hee Lee et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Role of sestrin2 in peroxide signaling in macrophages

Silke Essler et al.

FEBS LETTERS (2009)

Article Multidisciplinary Sciences

Presenilins are essential for regulating neurotransmitter release

Chen Zhang et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

Alan H. Nagahara et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling

Andrei V. Budanov et al.

Article Neurosciences

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Sofia Papadia et al.

NATURE NEUROSCIENCE (2008)

Review Neurosciences

Intracellular amyloid-β in Alzheimer's disease

Frank M. LaFerla et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

The antioxidant function of the p53 tumor suppressor

AA Sablina et al.

NATURE MEDICINE (2005)

Article Biochemistry & Molecular Biology

Protective effects of S-nitrosoglutathione against amyloid β-peptide neurotoxicity

TC Ju et al.

FREE RADICAL BIOLOGY AND MEDICINE (2005)

Article Biotechnology & Applied Microbiology

Drug repositioning: Identifying and developing new uses for existing drugs

TT Ashburn et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Review Biochemistry & Molecular Biology

Oxidative stress in neurodegeneration: cause or consequence?

JK Andersen

NATURE MEDICINE (2004)

Article Biochemistry & Molecular Biology

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

AV Budanov et al.

ONCOGENE (2002)