4.7 Article

Pathophysiological Mechanisms in Non-Alcoholic Fatty Liver Disease: From Drivers to Targets

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

Susanne Gaul et al.

Summary: The study found that hepatocyte pyroptosis, caused by NLRP3 inflammasome activation, leads to the release of inflammasome proteins and exacerbates fibrogenesis. Inhibition of caspase-1 and gasdermin D activation can prevent pyroptosis. The released inflammasomes are taken up by hepatic stellate cells, promoting inflammation and fibrosis. These findings suggest a novel mechanism for liver injury and potential therapeutic targets for chronic liver diseases.

JOURNAL OF HEPATOLOGY (2021)

Review Microbiology

Gut microbial metabolites as multi-kingdom intermediates

Kimberly A. Krautkramer et al.

Summary: The gut microbiota influences host physiology through the production of various metabolites. By studying microbial metabolites, researchers have identified potential microbial targets relevant for host health, despite the challenges of understanding host-microbiota interactions.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Microbiology

Gut microbiota in human metabolic health and disease

Yong Fan et al.

Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.

NATURE REVIEWS MICROBIOLOGY (2021)

Editorial Material Gastroenterology & Hepatology

Phage Therapy for Alcohol-Associated Hepatitis

Gina A. Suh

HEPATOLOGY (2021)

Article Medicine, General & Internal

Small intestinal bacterial overgrowth and non-alcoholic fatty liver disease diagnosed by transient elastography and liver biopsy

Ivana Mikolasevic et al.

Summary: This study demonstrated a higher incidence of SIBO in NASH patients and those with SF, with significant predictors associated with SIBO including T2DM, fibrosis stage, and ballooning grade. Elastographic parameters did not show significant correlation with SIBO compared to histological characteristics of NAFLD.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

Review Biochemistry & Molecular Biology

Immunity as Cornerstone of Non-Alcoholic Fatty Liver Disease: The Contribution of Oxidative Stress in the Disease Progression

Marcello Dallio et al.

Summary: NAFLD is a major cause of chronic liver disease in western countries, characterized by a wide spectrum of hepatic histological alterations. NASH is defined by lobular inflammation and fibrosis, with insulin resistance, redox unbalance, inflammation, and lipid metabolism dysregulation implicated in NAFLD progression. Recent findings suggest that oxidative products and immune cell metabolism play key roles in driving inflammation and fibrosis in NAFLD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low-grade inflammation via blockade of Kupffer cell M1 polarization

Yue Yin et al.

Summary: The study revealed that ghrelin blocks the progression of NASH induced by LPS by attenuating Kupffer cells M1 polarization. Ghrelin may serve as a marker and therapeutic target for NASH.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Pharmacology & Pharmacy

Interrogation of selected genes influencing serum LDL-Cholesterol levels in patients with well characterized NAFLD

Eduardo Vilar-Gomez et al.

Summary: Mutations in the APOB gene are common among NAFLD patients with very low LDL-C, and may be associated with increased aminotransferase levels and steatosis severity.

JOURNAL OF CLINICAL LIPIDOLOGY (2021)

Article Medicine, Research & Experimental

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKC epsilon/insulin receptor Thr(1160) phosphorylation

Kun Lyu et al.

Summary: Short-term high-fat diet may cause WAT insulin resistance by promoting PM sn-1,2-DAG accumulation and activating PKCe, impairing insulin signaling. Experiments showed that HFD feeding led to WAT IR, and Insr Thr1160 phosphorylation plays a crucial role in mediating lipid-induced WAT IR.

JCI INSIGHT (2021)

Article Medicine, General & Internal

Nonalcoholic fatty liver disease or metabolic dysfunction-associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches

Paola Dongiovanni et al.

Summary: NAFLD is associated with a higher risk of CVD, which may be improved through dietary interventions. Genetic factors, such as the PNPLA3 variant, may not directly cause CVD risk, while other variants like TM6SF2 may be protective and MBOAT7 may contribute to venous thromboembolism.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Gastroenterology & Hepatology

Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH

Rohit Loomba et al.

Summary: In patients with bridging fibrosis and cirrhosis, 48 weeks of treatment with cilofexor/firsocostat was well tolerated and resulted in improvements in NASH activity, potentially having an antifibrotic effect. This combination offers potential for fibrosis regression with longer-term therapy in patients with advanced fibrosis attributable to NASH.

HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial

V. Ratziu et al.

Summary: Aramchol showed potential improvements in liver steatosis and fibrosis in NASH patients, but did not significantly reduce hepatic triglycerides. However, it demonstrated positive effects on liver histology and ALT levels in the clinical trial.

NATURE MEDICINE (2021)

Article Biochemistry & Molecular Biology

ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials

Roberto A. Calle et al.

Summary: The study showed that ACC1/2 inhibitors had a good therapeutic effect in the treatment of non-alcoholic fatty liver disease, significantly reducing liver fat content. Co-administration of PF-05221304 and PF-06865571 can reduce the incidence of adverse events and mitigate the effect of ACC inhibition on serum triglycerides.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

Sven M. Francque et al.

Summary: In a randomized trial, the pan-PPAR agonist Lanifibranor showed significant improvement in histologic features of NASH at a dose of 1200 mg. However, adverse events such as weight gain, anemia, peripheral edema, diarrhea, and nausea were more common with Lanifibranor compared to placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Analysis of steatosis biomarkers and inflammatory profile after adding on PCSK9 inhibitor treatment in familial hypercholesterolemia subjects with nonalcoholic fatty liver disease: A single lipid center real-world experience

Roberto Scicali et al.

Summary: The study focused on observing nonalcoholic fatty liver disease (NAFLD) in familial hypercholesterolemia (FH) patients, and the results demonstrated that PCSK9-i therapy significantly improved steatosis biomarkers in patients with low TG/HDL.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

Article Medicine, Research & Experimental

Efficacy and safety of endoscopic sleeve gastroplasty versus laparoscopic sleeve gastrectomy in obese subjects with Non-Alcoholic SteatoHepatitis (NASH): study protocol for a randomized controlled trial (TESLA-NASH study)

Lucia Lavin-Alconero et al.

Summary: NASH is a liver disease closely associated with obesity, and standard treatment involves diet and exercise, but with limited success. LSG is an effective weight loss surgery, but comes with postoperative complications, while endoscopic bariatric techniques offer less invasive and cost-effective obesity treatment options.

TRIALS (2021)

Article Physiology

Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice

Daniel Kucsera et al.

Summary: The study revealed critical sex-specific differences in middle-aged mice during NASH development, with female mice showing higher levels of inflammation and cholesterol metabolism, while male mice exhibited more pronounced fibrosis. Additionally, female mice displayed differences in inflammatory response and Kupffer cell population after CDAA diet feeding compared to male mice.

FRONTIERS IN PHYSIOLOGY (2021)

Review Immunology

Extracellular Vesicles as Inflammatory Drivers in NAFLD

Akshatha N. Srinivas et al.

Summary: NAFLD is a prevalent chronic liver disease driven by obesity and diabetes, with inflammation considered as a key factor in the development of NASH. Extracellular vesicles play a crucial role in driving inflammation in NAFLD.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study

Emanuel Fryk et al.

Summary: The study suggests that in obese individuals, hyperinsulinemia is mainly caused by elevated free fatty acids, which is a significant factor in the development of insulin resistance in obesity. Additionally, obese subjects with normal glycemia do not show significant differences in lipolysis compared to lean individuals.

EBIOMEDICINE (2021)

Review Biochemistry & Molecular Biology

Role of Insulin Resistance in MAFLD

Yoshitaka Sakurai et al.

Summary: Metabolic dysfunction is closely related to the development of non-alcoholic fatty liver disease (NAFLD), prompting consideration of renaming it as metabolic dysfunction-associated fatty liver disease (MAFLD). Factors such as obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome contribute to metabolic dysfunction, leading to insulin resistance and fat accumulation in the liver. Genetic factors also play a role in hepatic fat accumulation and fibrosis, exacerbating inflammation, fibrosis, and carcinogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Histone Deacetylase 1 Reduces Lipogenesis by Suppressing SREBP1 Transcription in Human Sebocyte Cell Line SZ95

Hye Sun Shin et al.

Summary: Proper regulation of histone acetylation is crucial for sebocyte lipogenesis, with inhibitors of p300 histone acetyltransferase leading to decreased expression of key lipogenic genes and decreased lipid droplet formation. In contrast, inhibition of histone deacetylase promotes lipogenesis by increasing the expression of these genes. These findings suggest a potential therapeutic strategy for skin diseases related to excess sebum production.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Dermatology

Non-alcoholic fatty liver disease and psoriasis - is there a shared proinflammatory network?

Johanna Heitmann et al.

Summary: Psoriasis and non-alcoholic fatty liver disease (NAFLD) share common inflammatory pathways, such as cytokines TNFα, IL-6, and IL-17. Pharmacological blockade of IL-17 may be a promising strategy for treating both psoriasis and NAFLD.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2021)

Article Medicine, Research & Experimental

Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

Kunimaro Furuta et al.

Summary: The study revealed that VCAM-1 plays a significant role in the pathogenesis of NASH, with increased expression observed in NASH mouse models and human NASH. Inhibition of VCAM-1 could attenuate diet-induced NASH in mice and may serve as a potential therapeutic strategy for human NASH.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Medicine, General & Internal

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Philip N. Newsome et al.

Summary: This phase 2 trial demonstrated that treatment with semaglutide resulted in a significantly higher percentage of patients with NASH resolution compared to placebo in patients with NASH, but did not show a significant between-group difference in the percentage of patients with an improvement in fibrosis stage.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Nutrition & Dietetics

The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights

Alessandro Federico et al.

Summary: Fructose, a naturally occurring simple sugar linked with glucose to form sucrose, is commonly found in hypercaloric food and beverages. Excessive fructose consumption is associated with the development and progression of NAFLD, leading to various detrimental effects on liver metabolism and potentially more severe clinical phenotypes.

NUTRIENTS (2021)

Review Environmental Sciences

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Oriol Juanola et al.

Summary: NAFLD is a common cause of chronic liver disease in the Western world, often caused by factors such as obesity, metabolic diseases, and environmental agents. Progression from simple hepatic steatosis to NASH can lead to liver cirrhosis and complications. Understanding the mechanisms that cause this progression is crucial for controlling the advancement of the disease.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Review Immunology

The Role of the Gut-Liver Axis in Metabolic Dysfunction-Associated Fatty Liver Disease

Rosa Martin-Mateos et al.

Summary: The intricate relationship between gut microbiota, intestinal barrier, immune system, and liver is essential for the pathogenesis of metabolic disorders like fatty liver disease. Diet is a key modulator of microbiota composition, affecting gut barrier stability and immune responses, leading to inflammation and liver dysfunction. Therapeutic strategies targeting the gut-liver-axis are being explored for potential treatments, and distinctive microbial signatures in the gut may provide non-invasive diagnostic tools for disease monitoring and severity assessment.

FRONTIERS IN IMMUNOLOGY (2021)

Review Gastroenterology & Hepatology

Systematic review and network meta-analysis: comparative efficacy of pharmacologic therapies for fibrosis improvement and resolution of NASH

Abdul M. Majzoub et al.

Summary: This study evaluated the efficacy of different pharmacological interventions in improving liver fibrosis and NASH resolution, and provided ranking and probability of various drugs. The results showed that drugs like obeticholic acid and semaglutide demonstrated promising effects in the treatment of NASH.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

Novel approaches to intervene gut microbiota in the treatment of chronic liver diseases

Chang Liu et al.

Summary: Recent investigations into gut microbiota reveal the crucial role of microbial community in various liver diseases, driving rapid development of innovative therapies such as fecal microbial transplantation and specific bacteriophages to intervene dysbiosis.

FASEB JOURNAL (2021)

Article Gastroenterology & Hepatology

TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial

Rohit Loomba et al.

Summary: TVB-2640 significantly reduced liver fat and improved biochemical, inflammatory, and fibrotic markers after 12 weeks, in a dose-dependent manner in patients with nonalcoholic steatohepatitis.

GASTROENTEROLOGY (2021)

Article Biochemistry & Molecular Biology

Unwrapping the mechanisms of ceramide and fatty acid-initiated signals leading to immune-inflammatory responses in obesity

Salih Kucuk et al.

Summary: Obesity is a global epidemic associated with various diseases, with ceramides elevated in obesity and related conditions, while n-3 PUFA demonstrate anti-inflammatory effects. Inhibition of ceramide synthesis can lead to an anti-inflammatory environment.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Empagliflozin Improves Metabolic and Hepatic Outcomes in a Non-Diabetic Obese Biopsy-Proven Mouse Model of Advanced NASH

Nikolaos Perakakis et al.

Summary: Empagliflozin has shown beneficial metabolic and hepatic effects (mainly anti-inflammatory) in non-diabetic DIO-NASH mice, improving glucose homeostasis and inflammation without affecting body weight, composition, or insulin sensitivity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial

Stephen A. Harrison et al.

Summary: The study demonstrated the efficacy of efruxifermin in treating NASH by significantly reducing HFF levels in patients, with an acceptable safety profile.

NATURE MEDICINE (2021)

Review Gastroenterology & Hepatology

New targets for NAFLD

Lucia Parlati et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide with no effective treatments currently available. Preclinical models have enhanced our understanding of its pathophysiology, and research on new therapeutic targets is ongoing.

JHEP REPORTS (2021)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease: A patient guideline

Sven M. Francque et al.

Summary: This patient guideline provides comprehensive information for patients with NAFLD, aiming to help patients better understand the disease and actively participate in its management through interaction with healthcare providers.

JHEP REPORTS (2021)

Article Gastroenterology & Hepatology

Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus

Lee-Lee Lai et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Article Gastroenterology & Hepatology

Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients

Jessica R. Allegretti et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Association Between PNPLA3 rs738409 C > G Variant and Liver-Related Outcomes in Patients With Nonalcoholic Fatty Liver Disease

Stefania Grimaudo et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

Fei Chen et al.

HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

γδ T Cells Promote Steatohepatitis by Orchestrating Innate and Adaptive Immune Programming

Alejandro Torres-Hernandez et al.

HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets

Seonghwan Hwang et al.

HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease in inflammatory bowel disease patients

Katerina Karaivazoglou et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Biochemistry & Molecular Biology

Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway

Charng-Cherng Chyau et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Physiology

Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

Federica Zatterale et al.

FRONTIERS IN PHYSIOLOGY (2020)

Article Multidisciplinary Sciences

Characterization of the immune cell landscape of patients with NAFLD

Tom Diedrich et al.

PLOS ONE (2020)

Article Gastroenterology & Hepatology

Effect of weight loss induced by laparoscopic sleeve gastrectomy on liver histology and serum adipokine levels

Ahmed Abdallah Salman et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Lytic cell death in metabolic liver disease

Jeremie Gautheron et al.

JOURNAL OF HEPATOLOGY (2020)

Review Biochemistry & Molecular Biology

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Katarzyna Kolczynska et al.

LIPIDS IN HEALTH AND DISEASE (2020)

Review Medicine, General & Internal

A Role for Gut Microbiome Fermentative Pathways in Fatty Liver Disease Progression

Paula Iruzubieta et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Gastroenterology & Hepatology

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Judith Aron-Wisnewsky et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis

Guillaume Lassailly et al.

GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

Comparison of MAFLD and NAFLD diagnostic criteria in real world

Su Lin et al.

LIVER INTERNATIONAL (2020)

Article Endocrinology & Metabolism

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

Nikolaos Perakakis et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

Article Gastroenterology & Hepatology

MAFLD identifies patients with significant hepatic fibrosis better than NAFLD

Sakura Yamamura et al.

LIVER INTERNATIONAL (2020)

Review Cell Biology

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Patricia Rada et al.

CELL DEATH & DISEASE (2020)

Review Endocrinology & Metabolism

Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies

Carmelo Luci et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Oxidation-Specific Epitopes in Non-Alcoholic Fatty Liver Disease

Tim Hendrikx et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Gastroenterology & Hepatology

Stratification of patients in NASH clinical trials: A pitfall for trial success

Javier Ampuero et al.

JHEP REPORTS (2020)

Article Gastroenterology & Hepatology

Donor Fecal Microbiota Transplantation Alters Gut Microbiota and Metabolites in Obese Individuals With Steatohepatitis

Julia J. Witjes et al.

HEPATOLOGY COMMUNICATIONS (2020)

Review Gastroenterology & Hepatology

Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta-Analysis

Steven Young et al.

HEPATOLOGY COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Animal models of NAFLD from a hepatologist's point of view

Daniel Jahn et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Gastroenterology & Hepatology

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

Suzanne R. Sharpton et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

Review Biochemistry & Molecular Biology

Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application

Dicky Struik et al.

CURRENT OPINION IN LIPIDOLOGY (2019)

Article Gastroenterology & Hepatology

Neutrophil-to-lymphocyte ratio is independently associated with inflammatory activity and fibrosis grade in nonalcoholic fatty liver disease

Tawfik Khoury et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Immunology

Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease

Natalie Stiglund et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Environmental Sciences

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Valerio Rosato et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

Review Endocrinology & Metabolism

MAIT cells in metabolic diseases

Leo Bertrand et al.

MOLECULAR METABOLISM (2019)

Article Biochemistry & Molecular Biology

Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism

Jin Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges

Ziyi Song et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Yi Duan et al.

NATURE (2019)

Review Immunology

ILC-poiesis: Ensuring tissue ILC differentiation at the right place and time

Ai Ing Lim et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

Review Gastroenterology & Hepatology

Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease

Reenam S. Khan et al.

HEPATOLOGY (2019)

Article Medicine, Research & Experimental

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

Yongsheng Yu et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Endocrinology & Metabolism

Metabolically healthy versus metabolically unhealthy obesity

Carla Iacobini et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

Review Gastroenterology & Hepatology

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Konstantin Kazankov et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Gastroenterology & Hepatology

Resolving the Paradox of Hepatic Insulin Resistance

Dominic Santoleri et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Mortality Related to Nonalcoholic Fatty Liver Disease Is Increasing in the United States

James M. Paik et al.

HEPATOLOGY COMMUNICATIONS (2019)

Review Gastroenterology & Hepatology

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease

Suzanne R. Sharpton et al.

HEPATOLOGY COMMUNICATIONS (2019)

Review Gastroenterology & Hepatology

From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options

Amalia Gastaldelli et al.

JHEP REPORTS (2019)

Review Gastroenterology & Hepatology

Lifestyle modification in NAFLD/NASH: Facts and figures

Kate Hallsworth et al.

JHEP REPORTS (2019)

Review Gastroenterology & Hepatology

Metabolic Targets in Nonalcoholic Fatty Liver Disease

William P. Esler et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)

Review Biochemistry & Molecular Biology

Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer

Rosa Divella et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Physiology

Mice lacking PKC-theta in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle

Bailey Peck et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2018)

Article Endocrinology & Metabolism

Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

Alessandro Mantovani et al.

DIABETES CARE (2018)

Article Biochemistry & Molecular Biology

B2-Lymphocyte responses to oxidative stress-derived antigens contribute to the evolution of nonalcoholic fatty liver disease (NAFLD)

Stefania Bruzzi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Review Gastroenterology & Hepatology

Noninvasive, Quantitative Assessment of Liver Fat by MRI-PDFF as an Endpoint in NASH Trials

Cyrielle Caussy et al.

HEPATOLOGY (2018)

Article Endocrinology & Metabolism

Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial

Helena W. Rodbard et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Review Medicine, Research & Experimental

Fructose metabolism and metabolic disease

Sarah A. Hannou et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Gastroenterology & Hepatology

A Multi-strain Probiotic Reduces the Fatty Liver Index, Cytokines and Aminotransferase levels in NAFLD Patients: Evidence from a Randomized Clinical Trial

Nazarii Kobyliak et al.

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES (2018)

Review Immunology

Immune Responses in the Liver

Paul Kubes et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

Meeting Abstract Gastroenterology & Hepatology

Novel link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

C. Caussy et al.

JOURNAL OF HEPATOLOGY (2018)

Meeting Abstract Gastroenterology & Hepatology

JKB-121 in patients with nonalcoholic steatohepatitis: A phase 2 double blind randomized placebo control study

A. M. Diehl et al.

JOURNAL OF HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Lipotoxicity and the gut-liver axis in NASH pathogenesis

Fabio Marra et al.

JOURNAL OF HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Implications for liver transplantation

Zobair M. Younossi

LIVER TRANSPLANTATION (2018)

Review Biochemistry & Molecular Biology

Mechanisms of NAFLD development and therapeutic strategies

Scott L. Friedman et al.

NATURE MEDICINE (2018)

Review Gastroenterology & Hepatology

The gut-liver axis and the intersection with the microbiome

Anupriya Tripathi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease

Fabian J. Bolte et al.

SEMINARS IN LIVER DISEASE (2018)

Article Multidisciplinary Sciences

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Pushpa Hegde et al.

NATURE COMMUNICATIONS (2018)

Editorial Material Medicine, General & Internal

Dietary carbohydrates: role of quality and quantity in chronic disease

David S. Ludwig et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Editorial Material Medicine, General & Internal

Dietary carbohydrates: role of quality and quantity in chronic disease

David S. Ludwig et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Endocrinology & Metabolism

Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial

Richard E. Pratley et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

Review Endocrinology & Metabolism

Role of Innate Immune Signaling in Non-Alcoholic Fatty Liver Disease

Jingjing Cai et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Review Endocrinology & Metabolism

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

Jordan Rowlands et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Histopathological differences in patients with biopsy-proven non-alcoholic fatty liver disease with and without type 2 diabetes

Rocio Aller de la Fuente et al.

ENDOCRINOLOGIA DIABETES Y NUTRICION (2018)

Article Gastroenterology & Hepatology

Combined effects of synbiotic and sitagliptin versus sitagliptin alone in patients with nonalcoholic fatty liver disease

Saba Sayari et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Natural History of Nonalcoholic Fatty Liver Disease: A Prospective Follow-Up Study With Serial Biopsies

Patrik Nasr et al.

HEPATOLOGY COMMUNICATIONS (2018)

Review Endocrinology & Metabolism

Posttranslational Modifications of Lipid-Activated Nuclear Receptors: Focus on Metabolism

Natalia Becares et al.

ENDOCRINOLOGY (2017)

Article Endocrinology & Metabolism

Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial

Catherine M. Viscoli et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Gastroenterology & Hepatology

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

Cristina Alonso et al.

GASTROENTEROLOGY (2017)

Review Endocrinology & Metabolism

Adapting to obesity with adipose tissue inflammation

Shannon M. Reilly et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Multidisciplinary Sciences

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

Claire Duvallet et al.

NATURE COMMUNICATIONS (2017)

Article Medicine, General & Internal

Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis A Meta-analysis

Giovanni Musso et al.

JAMA INTERNAL MEDICINE (2017)

Article Medicine, Research & Experimental

TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival

Auvro R. Mridha et al.

CLINICAL SCIENCE (2017)

Article Endocrinology & Metabolism

Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice

Rongying Ou et al.

ENDOCRINE (2017)

Article Gastroenterology & Hepatology

Hepatic Natural Killer T-Cell and CD8+ T-Cell Signatures in Mice with Nonalcoholic Steatohepatitis

Jashdeep Bhattacharjee et al.

HEPATOLOGY COMMUNICATIONS (2017)

Article Gastroenterology & Hepatology

Treating Fatty Liver Disease by Modulating Mitochondrial Pyruvate Metabolism

Jerry R. Colca et al.

HEPATOLOGY COMMUNICATIONS (2017)

Review Immunology

Liver macrophages in tissue homeostasis and disease

Oliver Krenkel et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Gastroenterology & Hepatology

Endoscopic Sleeve Gastroplasty Significantly Reduces Body Mass Index and Metabolic Complications in Obese Patients

Reem Z. Sharaiha et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2017)

Review Immunology

Hepatocytes: a key cell type for innate immunity

Zhou Zhou et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2016)

Article Endocrinology & Metabolism

Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis

Stergios A. Polyzos et al.

DIABETOLOGIA (2016)

Article Psychiatry

Association of body composition and eating behavior in the normal weight obese syndrome

Laura Di Renzol et al.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2016)

Review Immunology

Hepatocytes as Immunological Agents

Ian N. Crispe

JOURNAL OF IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

Eiji Kakazu et al.

JOURNAL OF LIPID RESEARCH (2016)

Review Physiology

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

Joel T. Haas et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 78 (2016)

Review Gastroenterology & Hepatology

Innate Immunity and Inflammation in NAFLD/NASH

Marco Arrese et al.

DIGESTIVE DISEASES AND SCIENCES (2016)

Article Gastroenterology & Hepatology

NKp46+ Natural Killer Cells Attenuate Metabolism-Induced Hepatic Fibrosis by Regulating Macrophage Activation in Mice

Annie-Carole Tosello-Trampont et al.

HEPATOLOGY (2016)

Article Medicine, Research & Experimental

ChREBP regulates fructose-induced glucose production independently of insulin signaling

Mi-Sung Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, Research & Experimental

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Irma Garcia-Martinez et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Gastroenterology & Hepatology

EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

Giulio Marchesini et al.

JOURNAL OF HEPATOLOGY (2016)

Article Endocrinology & Metabolism

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

Manoela Mota et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Article Medicine, General & Internal

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Endocrinology & Metabolism

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis

Mark A. Herman et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)

Article Cell Biology

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

Steven Zhao et al.

CELL REPORTS (2016)

Article Endocrinology & Metabolism

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

Gabriele Forlani et al.

JOURNAL OF DIABETES RESEARCH (2016)

Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

N. U. Ashraf et al.

FREE RADICAL RESEARCH (2015)

Article Gastroenterology & Hepatology

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

Eduardo Vilar-Gomez et al.

GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease

Johannie du Plessis et al.

GASTROENTEROLOGY (2015)

Article Endocrinology & Metabolism

Effect of Vildagliptin on Hepatic Steatosis

Mavin Macauley et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Review Gastroenterology & Hepatology

NAFLD: A multisystem disease

Christopher D. Byrne et al.

JOURNAL OF HEPATOLOGY (2015)

Review Biotechnology & Applied Microbiology

The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease

Maria Teresa Arias-Loste et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Medicine, Research & Experimental

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic

Chris J. Weston et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Nutrition & Dietetics

Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study

Tannaz Eslamparast et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2014)

Article Gastroenterology & Hepatology

IL-17 Signaling Accelerates the Progression of Nonalcoholic Fatty Liver Disease in Mice

Isaac T. W. Harley et al.

HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

The Portal Inflammatory Infiltrate and Ductular Reaction in Human Nonalcoholic Fatty Liver Disease

Victoria L. Gadd et al.

HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Glucose Transporter 8 (GLUT8) Mediates Fructose- induced de Novo Lipogenesis and Macrosteatosis

Brian J. DeBosch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

Callie A. Norris et al.

PLOS ONE (2014)

Article Gastroenterology & Hepatology

IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet

Xiao-Yu Luo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Review Biochemistry & Molecular Biology

PPARγ signaling and metabolism: the good, the bad and the future

Maryam Ahmadian et al.

NATURE MEDICINE (2013)

Review Cell Biology

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Christopher K. Glass et al.

CELL METABOLISM (2012)

Review Gastroenterology & Hepatology

Sterile Inflammation in the Liver

Paul Kubes et al.

GASTROENTEROLOGY (2012)

Article Immunology

The Role of Innate Cells Is Coupled to a Th1-Polarized Immune Response in Pediatric Nonalcoholic Steatohepatitis

Nazarena E. Ferreyra Solari et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2012)

Article Immunology

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

Y. Tang et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2011)

Article Oncology

Increased production of sonic hedgehog by ballooned hepatocytes

Fatima Rangwala et al.

JOURNAL OF PATHOLOGY (2011)

Review Endocrinology & Metabolism

Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2011)

Article Gastroenterology & Hepatology

Intrahepatic natural killer T cell populations are increased in human hepatic steatosis

Michael Adler et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2011)

Article Gastroenterology & Hepatology

Kupffer Cell and Interleukin-12-Dependent Loss of Natural Killer T Cells in Hepatosteatosis

Michael Kremer et al.

HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

Accumulation of Natural Killer T Cells in Progressive Nonalcoholic Fatty Liver Disease

Wing-Kin Syn et al.

HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet

Takuya Miyagi et al.

JOURNAL OF GASTROENTEROLOGY (2010)

Article Medicine, General & Internal

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis.

Arun J. Sanyal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Gastroenterology & Hepatology

Roles of liver innate immune cells in nonalcoholic fatty liver disease

Yu-Tao Zhan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

Article Pathology

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

Sander S. Rensen et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Article Gastroenterology & Hepatology

Role of liver-infiltrating CD3(+)CD56(+) natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease

Kazuto Tajiri et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Activation of the Complement System in Human Nonalcoholic Fatty Liver Disease

Sander S. Rensen et al.

HEPATOLOGY (2009)

Article Biochemistry & Molecular Biology

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Satoshi Nishimura et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

Apoptosis in alcoholic and nonalcoholic steatohepatitis

AE Feldstein et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2005)

Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)