期刊
BIOMEDICINES
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10010111
关键词
taurocholic acid; tissue engineering; tissue encapsulation; transplantation; surgery
资金
- European Union Horizon
- Marie Sklodowska-Curie Grant Agreement [872370]
- Curtin Faculty ORS-WAHAI Consortium and the Australian National Health and Medical Research [APP9000597]
- Marie Curie Actions (MSCA) [872370] Funding Source: Marie Curie Actions (MSCA)
This study aimed to investigate the biological effects of graft that encapsulates TCA and islets on diabetic mice, and found that the graft improved glucose and interleukin-6 levels, while reducing LCA concentrations in various tissues.
A recent study showed an association between diabetes development and the bile acid lithocholic acid (LCA), while another study demonstrated positive biological effects of the conjugated bile acid, taurocholic acid (TCA), on pancreatic cells. Thus, this study aimed to encapsulate TCA with primary islets (graft) and study the biological effects of the graft, post-transplantation, in diabetic mice, including effects on LCA concentrations. Sixteen mature adult mice were made diabetic and randomly divided into two equal groups, control and test (transplanted encapsulated islets without or with TCA). Graft pharmaceutical features pre-transplantation, and biological effects including on LCA concentrations post-transplantation, were measured. TCA-microcapsules had an oval shape and similar size compared with the control. The treatment group survived longer, showed improved glucose and interleukin-6 concentrations, and lower LCA concentrations in plasma, large intestine, faeces, liver and spleen, compared with control. Results suggest that TCA incorporation with islets encapsulated graft exerted beneficial effects, but there was no direct and significant dependency between concentrations of interleukin-6 and LCA.
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