Rodent Brain Pathology, Audiogenic Epilepsy

The review presents data which provides evidence for the internal relationship between the stages of rodent audiogenic seizures and post-ictal catalepsy with the general pattern of animal reaction to the dangerous stimuli and/or situation. The wild run stage of audiogenic seizure fit could be regarded as an intense panic reaction, and this view found support in numerous experimental data. The phenomenon of audiogenic epilepsy probably attracted the attention of physiologists as rodents are extremely sensitive to dangerous sound stimuli. The seizure proneness in this group shares common physiological characteristics and depends on animal genotype. This concept could be the new platform for the study of epileptogenesis mechanisms.

Automated summary

The review discusses the internal relationship between stages of rodent audiogenic seizures and post-ictal catalepsy, highlighting a potential platform for studying epileptogenesis mechanisms. It suggests that the wild run stage of audiogenic seizure could be seen as an intense panic reaction, supported by experimental data. This phenomenon is of interest to physiologists due to rodents' sensitivity to dangerous sound stimuli.