期刊
BIOMEDICINES
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10020376
关键词
salt-sensitive hypertension; spontaneously hypertensive rat; skin; sodium; salt; blood pressure; capillary rarefaction; gene expression
Recent studies found that increased Na+ storage in the skin without water retention may lead to salt-sensitive hypertension. This study compared the tissue Na+ storage in salt sensitive spontaneously hypertensive rats (SHR) and salt resistant normotensive Brown Norway (BN-Lx) rats. After salt loading, SHR showed increased osmotically inactive Na+ storage in the skin, while BN-Lx rats did not show significant changes in skin electrolyte concentrations. SHR rats also exhibited decreased skin blood capillary number, while BN-Lx rats showed increased skin blood capillary density. Gene expression analysis showed up-regulation of genes involved in angiogenesis and endothelial cell proliferation in BN-Lx rats after salt treatment.
Recent studies in humans and rats suggested that increased Na+ storage in the skin without parallel water retention may predispose to salt-sensitive hypertension. In the current studies, we compared tissue Na+ storage in salt sensitive spontaneously hypertensive rats (SHR) versus salt resistant normotensive Brown Norway (BN-Lx) rats. After salt loading (10 days drinking 1% NaCl solution), the SHR showed significant parallel increase in Na+-to-water as well as (Na++K+)-to-water ratios suggesting increased storage of osmotically inactive Na+ in the skin while no significant changes in skin electrolyte concentrations were observed in BN-Lx rats. SHR rats after salt treatment exhibited a nonsignificant decrease in skin blood capillary number (rarefaction) while BN-Lx rats showed significantly increased skin blood capillary density. Analysis of dermal gene expression profiles in BN-Lx rats after salt treatment showed significant up-regulation of genes involved in angiogenesis and proliferation of endothelial cells contrary to the SHR. Since the skin harbors most of the body's resistance vessels it is possible that blood capillary rarefaction may lead to increased peripheral resistance and salt sensitivity in the SHR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据