What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review (Part 6): Correlation of PD-L1 Expression with the Status of Mismatch Repair System, BRCA, PTEN, and Other Genes

Review Surgery

Systematic Review on the Mid-Term Outcomes of Elective Endovascular Aneurysm Sealing in Comparison to Endovascular Aneurysm Repair

Zoethout C. Aleksandra et al.

Summary: This study compared EVAS and EVAR in the literature, finding lower mortality and overall endoleak rates for EVAS compared to EVAR, but with higher rates of migration, aneurysm growth, and reintervention.

JOURNAL OF ENDOVASCULAR THERAPY (2022)

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Review Geriatrics & Gerontology

Tackling Dementia: A Systematic Review of Interventions Based on Physical Activity

Lu Liu et al.

Summary: The aim of this systematic review is to gather the latest evidence of the effects of physical activity interventions on cognition and noncognitive functions of older people with dementia. The results showed that physical activity interventions have a positive impact on the physical function, mobility, and activities of daily living of older people with dementia, but the effects on cognitive function are still uncertain.

JOURNAL OF GERIATRIC PHYSICAL THERAPY (2022)

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Review Pathology

Risk Assessment in Solitary Fibrous Tumor of the Uterine Corpus: Report of a Case and Systematic Review of the Literature

Laura Ardighieri et al.

Summary: Solitary fibrous tumor (SFT) is a rare fibroblastic tumor that mostly occurs in the pleura but can also be found in other sites such as the uterus. Research indicates that tumor recurrences/metastases may occur in a minority of uterine SFT patients, with clinical behavior being difficult to predict, thus recommending extended follow-up for all cases.

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY (2022)

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Review Urology & Nephrology

Perioperative Outcomes of Holmium Laser Enucleation of the Prostate: A Systematic Review

Angelo Porreca et al.

Summary: Holmium laser enucleation of the prostate (HoLEP) is a safe procedure with a low overall complication rate. Most reported perioperative complications are not severe, falling into Clavien-Dindo classification grades 1-2. Further randomized studies are necessary to fully understand and prevent surgical complications for continued improvement of this technique.

UROLOGIA INTERNATIONALIS (2022)

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Article Oncology

Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study

Qinchuan Wang et al.

Summary: This study investigated the role of serum immune-checkpoint-related proteins and genetic variations in predicting outcomes of localized prostate cancer. The results showed that certain proteins and genetic variations were associated with aggressiveness, biochemical recurrence, and progression of PCa. These findings suggest that serum biomarkers and genetic factors could serve as potential predictors and targets for localized PCa.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Endocrinology & Metabolism

Association between CD8 and PD-L1 expression and outcomes after radical prostatectomy for localized prostate cancer

Cecile Vicier et al.

Summary: The study found that lower CD8 and/or higher PD-L1 expression in localized prostate tumors were associated with a shorter time to biochemical recurrence and metastasis-free survival. However, neither low CD8 nor high PD-L1 alone were independent predictors of recurrence or metastasis, but the combination of low CD8 and/or high PD-L1 was associated with significantly shorter time to recurrence and metastasis-free survival.

PROSTATE (2021)

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Review Obstetrics & Gynecology

Mitotically Active Cellular Fibroma of the Ovary Recurring After the Longest Interval of Time (16 yr): A Challenging Case With Systematic Literature Review

Rocco Olivadese et al.

Summary: Cellular fibromas, accounting for around 10% of ovarian fibromas, usually have a benign clinical course. However, recurrence may occur after a long interval, warranting thorough sampling to exclude malignant areas in challenging cases.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2021)

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Article Oncology

Immune response drives outcomes in prostate cancer: implications for immunotherapy

Jialin Meng et al.

Summary: A new immune molecular classifier was proposed in this study to classify prostate cancer patients into different immune-activated and immune-suppressed subtypes. The immune-activated subtype was found to be associated with favorable recurrence-free survival outcomes and was predicted to benefit more from anti-PD-1/PD-L1 therapy.

MOLECULAR ONCOLOGY (2021)

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Article Endocrinology & Metabolism

Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD-L1 expression by C5a

Ryuji Imamura et al.

Summary: The study demonstrated that PC cells express C5aR in patients' tissues, with C5a enhancing CRPC cell proliferation, invasion, and PD-L1 expression. The C5a-C5aR system plays a role in CRPC promotion and evasion from antitumor immune responses. Targeting this signaling pathway may offer a potential therapeutic option for CRPC.

PROSTATE (2021)

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Review Biochemistry & Molecular Biology

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 3: PD-L1, Intracellular Signaling Pathways and Tumor Microenvironment

Andrea Palicelli et al.

Summary: The tumor microenvironment influences the survival and progression of cancer cells through the activation of the PD-1/PD-L1 axis, enabling immune evasion. Experimental studies have shown that various signaling pathways are involved in the upregulation of PD-L1 in prostate cancer, and using immunotherapy drugs can prevent tumor immune evasion.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 4: Experimental Treatments in Pre-Clinical Studies (Cell Lines and Mouse Models)

Andrea Palicelli et al.

Summary: The PD-1/PD-L1 axis plays a crucial role in prostate cancer, with various treatments showing effects on PD-L1 signaling in pre-clinical studies. Manipulation of PD-L1 signaling can enhance immunotherapy efficacy in prostate cancer patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 5: Epigenetic Regulation of PD-L1

Andrea Palicelli et al.

Summary: Epigenetic alterations impact the expression of PD-L1 in prostate cancer, with DNA methylation and miRNAs being key factors. Histone modifiers and epigenetic drugs can reverse these alterations. miRNAs can regulate PD-L1 post-transcriptionally, offering potential clinical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Primary Pulmonary B-Cell Lymphoma: A Review and Update

Francesca Sanguedolce et al.

Summary: This article provides a comprehensive overview of primary pulmonary B-cell lymphomas, discussing their clinical, radiological, pathological, and molecular characteristics and highlighting the importance of multidisciplinary management. Primary pulmonary B-cell lymphomas include entities such as PP-MZL, PP-DLBCL, and LYG, necessitating a collaborative approach involving radiologists, pneumologists, pathologists, and other specialists for accurate diagnosis and risk assessment.

CANCERS (2021)

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Article Microbiology

Klebsiella pneumoniae Chorioamnionitis: An Underrecognized Cause of Preterm Premature Rupture of Membranes in the Second Trimester

Maria Paola Bonasoni et al.

Summary: Klebsiella pneumoniae infection leading to acute chorioamnionitis caused intrauterine fetal demise in a case presented here. The mother was admitted at 18 weeks + 1 day for threatened abortion, with IUFD occurring 11 days later. The correct treatment was initiated based on fetal microbiological results, leading to full patient recovery.

MICROORGANISMS (2021)

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Editorial Material Medicine, General & Internal

Systemic Mastocytosis Associated with Smoldering Multiple Myeloma

Magda Zanelli et al.

Summary: A 79-year-old woman presented with peripheral eosinophilia, with a history of colonic polyposis and subsequent right hemicolectomy. Laboratory tests revealed mild macrocitic anaemia, elevated beta 2 microglobulin and serum tryptase levels, and the presence of IgA/kappa monoclonal protein and Bence-Jones protein. Bone marrow biopsy showed two neoplastic components - mast cells and plasma cells, with molecular analysis demonstrating mutations and chromosomal abnormalities. The rare coexistence of systemic mastocytosis and multiple myeloma led to treatment with midostaurin therapy.

DIAGNOSTICS (2021)

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Article Oncology

Safety and Clinical Activity of Atezolizumab in Patients with Metastatic Castration-Resistant Prostate Cancer: A Phase I Study

Daniel P. Petrylak et al.

Summary: Atezolizumab monotherapy showed good tolerability and evidence of disease control in patients with metastatic castration-resistant prostate cancer (mCRPC), albeit with limited efficacy. Further studies are needed to evaluate the potential benefits of combination therapy in this population.

CLINICAL CANCER RESEARCH (2021)

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Article Oncology

A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study

Elizabeth K. Bancroft et al.

Summary: The IMPACT study found that men carrying pathogenic variants in the MLH1, MSH2, and MSH6 genes had a significantly higher incidence of prostate cancer after the first round of PSA screening, supporting the use of targeted PSA screening in these men to identify clinically significant prostate cancer.

LANCET ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Avelumab maintenance in advanced urothelial carcinoma: biomarker analysis of the phase 3 JAVELIN Bladder 100 trial

Thomas Powles et al.

Summary: In a recent study of advanced urothelial cancer patients, avelumab in combination with best supportive care significantly prolonged overall survival compared to care alone, with factors such as PD-L1 expression, tumor mutational burden, immune activity genes, and Fcγ receptor variants being positively associated with survival benefit. Individual biomarkers alone were not sufficient to predict therapy response, but multi-parameter models integrating genomic alterations, immune responses, and tumor growth showed potential for predictive utility. These findings highlight the complexity of biological pathways in immune checkpoint inhibition therapy and suggest the need for multiple biomarkers to identify patients who would benefit from treatment.

NATURE MEDICINE (2021)

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Article Oncology

Cell membrane and nuclear expression of programmed death ligand-1 in prostate needle biopsy tissue in prostate cancer patients undergoing primary radiation therapy

Kang Hee Shim et al.

Summary: This study conducted a systematic analysis of PD-L1 expression in prostate cancer patients, revealing that 15% and 46% of biopsy cores were positive for mPD-L1 and nPD-L1, respectively. There was a positive correlation between Gleason score and mPD-L1, and a negative correlation between Gleason score and nPD-L1, with no significant correlation between mPD-L1 and nPD-L1. Additionally, both mPD-L1 and nPD-L1 expression were not predictive of BCR-free survival.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2021)

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Article Multidisciplinary Sciences

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Lauren Brady et al.

Summary: The study investigates the inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) using Digital Spatial Profiling, identifying high intra-patient homogeneity in tumor phenotype with exceptions. It also highlights the expression of the immune checkpoint protein B7-H3/CD276 in some mPCs with high androgen receptor (AR) activity, suggesting potential immunotherapy targets.

NATURE COMMUNICATIONS (2021)

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Article Oncology

N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells

Yi Sun et al.

Summary: The study showed that N-cadherin upregulated PD-L1 and IDO-1 expression through interferon-gamma signaling, promoting eTreg cell generation. ADH-1 effectively reduced immunosuppression and enhanced TIL-related therapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

How Can We Treat Vulvar Carcinoma in Pregnancy? A Systematic Review of the Literature

Andrea Palicelli et al.

Summary: Vulvar squamous cell carcinoma (VSCC) is the most common malignant vulvar tumor, with a peak incidence in the 7-8th decades of life, but can also occur in young women and pregnant patients. Treatment options for VSCCs diagnosed during pregnancy include before, after, or before-and-after delivery, with follow-up needed for patients. Larger cohorts and definite guidelines are necessary to determine the best treatment options for pregnant women with VSCC.

CANCERS (2021)

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Article Oncology

Prognostic Significance of Gene Expression and DNA Methylation Markers in Circulating Tumor Cells and Paired Plasma Derived Exosomes in Metastatic Castration Resistant Prostate Cancer

Martha Zavridou et al.

Summary: Liquid biopsy based on CTCs and ctDNA allows real-time monitoring of tumor progression and treatment efficacy. A study on gene expression and DNA methylation markers in CTCs and plasma-derived exosomes in metastatic prostate cancer patients revealed higher positivity in markers in CTCs compared to exosomes, correlating with overall survival.

CANCERS (2021)

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Article Medicine, General & Internal

Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease

Maria Paola Bonasoni et al.

Summary: K. kingae is a Gram-negative coccobacillus that can cause septic arthritis in children and endocarditis in adults. This study presents a case of intrauterine fetal death due to K. kingae infection, which is a rare occurrence in acute chorioamnionitis leading to preterm rupture of membranes and miscarriage.

DIAGNOSTICS (2021)

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Review Medicine, General & Internal

Immunohistochemical Biomarkers as a Surrogate of Molecular Analysis in Ovarian Carcinomas: A Review of the Literature

Giacomo Santandrea et al.

Summary: Ovarian carcinoma encompasses five different malignant neoplasms with distinctive features. The treatment of ovarian carcinoma requires an integrated multidisciplinary approach, with immunohistochemistry playing a key role as a surrogate for molecular analysis.

DIAGNOSTICS (2021)

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Article Oncology

Expression of immune checkpoints on circulating tumor cells in men with metastatic prostate cancer

Tian Zhang et al.

Summary: The study found that CTCs from men with mPC often express B7-H3, and there is heterogeneity in the expression of immune checkpoints PD-L1, PD-L2, and CTLA-4 across different disease states. Detection of these immune checkpoints in CTCs may aid in monitoring immunotherapy efficacy.

BIOMARKER RESEARCH (2021)

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Article Genetics & Heredity

Molecular profiling of advanced malignancies guides first-line N-of-1 treatments in the I-PREDICT treatment-naive study

Jason K. Sicklick et al.

Summary: Offering personalized combination therapies to treatment-naive, advanced cancer patients is both feasible and effective. The degree of matching in personalized therapies correlates with survival outcomes and higher Matching Score predicts improved disease control rate, PFS, and OS.

GENOME MEDICINE (2021)

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Article Medicine, Research & Experimental

ShRNA-mediated silencing of PD-1 augments the efficacy of chimeric antigen receptor T cells on subcutaneous prostate and leukemia xenograft

Jing-E Zhou et al.

Summary: CAR-T immunotherapy has shown promising results in treating leukemia and lymphoma, with limited effectiveness in solid tumors due to the PD-1/PD-L1 pathway. Utilizing shRNA gene-silencing technique to construct CAR-T cells with PD-1 silencing enhanced the anti-tumor effect in lymphoma and prostate subcutaneous xenograft models. PD-1 silencing improved killing ability and cytokine releasing ability of CAR-T cells, leading to significant tumor growth inhibition and prolonged survival in mice models.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

Pembrolizumab with or without enzalutamide in selected populations of men with previously untreated metastatic castration-resistant prostate cancer harbouring programmed cell death ligand-1 staining: a retrospective study

Huanyi Lin et al.

Summary: This retrospective study evaluated the survival outcomes of pembrolizumab (PEM) plus enzalutamide (ENZ) versus PEM alone in men with previously untreated metastatic castration-resistant prostate cancer (mCRPC) harbouring programmed cell death ligand-1 (PD-L1) staining. The study found that the combination treatment of PEM and ENZ significantly increased overall survival and progression-free survival compared to PEM alone, with a manageable safety profile.

BMC CANCER (2021)

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Review Oncology

Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence

Magda Zanelli et al.

Summary: Primary effusion lymphoma is a rare and often fatal post-transplant complication that can develop several years after transplantation. Clinicians should be suspicious of this condition in transplanted patients, especially those presenting with unexplained body cavity effusions.

BMC CANCER (2021)

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Article Oncology

Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment

Ioulia Vardaki et al.

Summary: The study found specific molecular differences in exosomes under Radium-223 treatment that may reflect the overall survival of patients, suggesting potential for monitoring treatment response. Furthermore, immune-suppressors related to the efficacy of Radium-223 were detected in exosomal transcripts from patients, indicating the potential of ICT to enhance the efficacy of Radium-223.

CLINICAL CANCER RESEARCH (2021)

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Review Oncology

EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3)

Magda Zanelli et al.

Summary: The Epstein-Barr virus (EBV) is a common virus infecting the majority of individuals early in life, but only a minority develop EBV-related diseases under conditions of immunosuppression. EBV-driven lymphoid proliferations can originate from B-cells or T/NK-cells, with behaviors ranging from indolent to aggressive, posing challenges for diagnosis and treatment.

CANCERS (2021)

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Review Cell Biology

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 1: Focus on Immunohistochemical Results with Discussion of Pre-Analytical and Interpretation Variables

Andrea Palicelli et al.

Summary: Immune checkpoint therapy targeting the PD-1-PD-L1 axis has shown promising results in treating immunologically ''hot'' tumors, with pembrolizumab demonstrating good therapeutic activity in selected prostate cancer patients. Analysis of PD-L1 expression in human prostate cancer samples revealed varying positivity rates across different histological subtypes, with different PD-L1 antibody clones showing differential expression patterns in tumor cells. Tumor heterogeneity, inter-institutional preanalytics, and variability in interpretation may lead to biases in results.

CELLS (2021)

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Review Cell Biology

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 2: Clinic-Pathologic Correlations

Andrea Palicelli et al.

Summary: PD-L1 expression may be associated with adverse clinic-pathologic features in prostatic carcinoma, especially in castration-resistant cases. Further standardized studies are needed to clarify the prognostic and predictive role of PD-L1.

CELLS (2021)

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Article Health Care Sciences & Services

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 7: PD-L1 Expression in Liquid Biopsy

Andrea Palicelli et al.

Summary: Liquid biopsy is a valuable tool for monitoring PD-L1 expression in PC patients, with potential correlations to prognosis and treatment efficacy. The discrepancies between primary and metastatic PC tissue biopsies, as well as between CTCs and tumor tissues, indicate the need for further research in larger sample sizes to determine the clinical implications of PD-L1 expression levels.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Biology

Cutaneous Localization of Classic Hodgkin Lymphoma Associated with Mycosis Fungoides: Report of a Rare Event and Review of the Literature

Magda Zanelli et al.

Summary: Mycosis fungoides and nodal classic Hodgkin lymphoma can occur concurrently or sequentially in the same patient. Skin involvement is a rare manifestation of nodal classic Hodgkin lymphoma, while mycosis fungoides more often precedes the onset of nodal cHL.

LIFE-BASEL (2021)

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Review Oncology

Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications

Francesca Sanguedolce et al.

Summary: The biological features and prognostic/predictive role of variant histology (VH) in non-muscle invasive bladder cancer (NMIBC) were examined through a systematic literature search, revealing conflicting findings due to the rarity of these forms and heterogeneity in study populations. The presence of VH should be considered when counseling NMIBC patients for potential disease upgrade to high-risk tumors and aggressive treatment.

ONCOLOGY (2021)

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Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Oncology

Immune Checkpoint Inhibitors in Urothelial Carcinoma: Recommendations for Practical Approaches to PD-L1 and Other Potential Predictive Biomarker Testing

Antonio Lopez-Beltran et al.

Summary: The workshops aimed to develop recommendations for best practice approaches to PD-L1 testing in UC, emphasizing the importance of robust control of analytical standards, clear communication for interpretation and reporting of PD-L1 results. In addition, a test request form for pathology laboratories was developed to facilitate communication between clinicians and pathologists for fast and high-quality test results. Novel biomarkers for immuno-oncology agents in UC were briefly discussed in the era of personalized medicine.

CANCERS (2021)

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Article Medicine, General & Internal

Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma

Julika Ribbat-Idel et al.

Summary: This study tested five different PD-L1 clones on primary HNSCC tumor tissue of 75 patients and found that the percentages of positive immune and tumor cells varied greatly. The choice of antibody strongly influenced the resulting combined positive score and eligibility for checkpoint inhibitor regimens. The study highlights the importance of determining PD-L1 expression for therapeutic decision making and suggests that back-to-back testing of different PD-L1 clones may be beneficial.

FRONTIERS IN MEDICINE (2021)

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Editorial Material Medicine, General & Internal

BRCA Germline Mutations in Prostate Cancer: The Future Is Tailored

Felice Crocetto et al.

DIAGNOSTICS (2021)

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Review Medicine, General & Internal

What Is New on Ovarian Carcinoma: Integrated Morphologic and Molecular Analysis Following the New 2020 World Health Organization Classification of Female Genital Tumors

Antonio De Leo et al.

Summary: Ovarian carcinomas are a heterogeneous group of neoplasms with different types and characteristics. The WHO classifies them into five distinct types, each with unique molecular features. Advances in molecular pathology have improved our understanding of ovarian carcinomas and can guide personalized clinical decisions.

DIAGNOSTICS (2021)

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Article Andrology

Significance of TP53 and immune-related genes to prostate cancer

Hang Huang et al.

Summary: Mutations in the TP53 gene can affect the prognosis of prostate cancer patients, and those with mutations in certain immune-related genes have a worse prognosis. By filtering differentially expressed genes, patients can be classified into high and low risk groups, which helps in predicting survival outcomes.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Review Urology & Nephrology

Impact of radiotherapy for localized prostate cancer on bladder function as demonstrated on urodynamics study: A systematic review

Henry Han- Yao et al.

Summary: Localized prostate cancer radiotherapy may lead to decreased bladder compliance and capacity, with the possibility of de novo detrusor overactivity developing in the long term. Bladder outlet obstruction tends to persist in most patients at three and 18 months post-radiotherapy.

CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL (2021)

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Article Health Care Sciences & Services

Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement

Matthew J. Page et al.

Summary: The study provides an overview of the processes used to update the PRISMA 2009 statement, including a survey of systematic review methodologists and journal editors, decisions made at the update meeting, and changes to the guideline.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Review Medicine, General & Internal

Solitary vulvar metastasis from early-stage endometrial cancer Case report and literature review

Vincenzo Dario Mandato et al.

Summary: Vulvar metastases of endometrial cancer are rare but associated with poor prognosis. Close monitoring, timely biopsy, and precautions against tumor seeding and vaginal injuries are necessary postoperatively.

MEDICINE (2021)

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Article Urology & Nephrology

Initial Findings from a High Genetic Risk Prostate Cancer Clinic

Michael S. Sessine et al.

Summary: This study aimed to improve prostate cancer screening for high-risk men by establishing an early detection clinic for patients at high genetic risk. The first 45 enrolled patients with known pathogenic germline variants in prostate cancer susceptibility genes underwent screening and biopsy, leading to early data that support the feasibility of personalized prostate cancer screening for this high-risk population.

UROLOGY (2021)

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Review Oncology

Gastrointestinal Manifestations in Systemic Mastocytosis: The Need of a Multidisciplinary Approach

Magda Zanelli et al.

Summary: Mastocytosis represents a heterogeneous group of neoplastic mast cell disorders, with gastrointestinal symptoms being a major cause of morbidity in patients. Diagnosing the disease can be challenging and requires a close multidisciplinary team approach for diagnosis and treatment.

CANCERS (2021)

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Review Oncology

EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 2)

Magda Zanelli et al.

Summary: Epstein-Barr virus (EBV) is a common pathogen that infects individuals early in life, primarily in B lymphocytes. Conditions of immunodeficiency and immunosuppressive therapies have brought attention to EBV-related lymphoproliferative disorders, which can range from indolent to aggressive lymphomas. These disorders can be diagnostically challenging due to overlapping morphology and immunophenotype.

CANCERS (2021)

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Review Oncology

EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 1)

Magda Zanelli et al.

Summary: Epstein-Barr virus (EBV) infection commonly occurs early in life and persists latently in B lymphocytes. Conditions of immunosuppression can lead to EBV-related lymphoid proliferations, spanning benign diseases to aggressive lymphomas. EBV-driven lesions in the gastrointestinal tract may present challenges for diagnosis due to overlapping features.

CANCERS (2021)

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Review Oncology

The Effects of Multidisciplinary Team Meetings on Clinical Practice for Colorectal, Lung, Prostate and Breast Cancer: A Systematic Review

Lejla Koco et al.

Summary: Multidisciplinary team meetings have been increasingly implemented in cancer care worldwide, with significant impacts on treatment decisions, patient outcomes, and process outcomes despite being time-consuming and expensive. Further high-quality research is needed to explore the impact of these meetings on healthcare quality.

CANCERS (2021)

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Review Oncology

Salvage Reirradiation Options for Locally Recurrent Prostate Cancer: A Systematic Review

Jim Zhong et al.

Summary: Salvage reirradiation of locally radiorecurrent prostate cancer using HDR-BT or SBRT provides similar biochemical control and acceptable late toxicity. Salvage LDR-BT is associated with higher late GU/GI toxicity. Challenges exist in comparing BT and SBRT, and prospective randomised trials are needed to provide more definitive conclusions.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, General & Internal

Fetal Presentation of Mediastinal Immature Teratoma: Ultrasound, Autopsy and Cytogenetic Findings

Maria Paola Bonasoni et al.

Summary: Teratomas are common congenital tumors that can be classified as mature or immature, with the potential to pose serious risks to the fetus. Prenatal diagnosis and treatment are crucial in ensuring the best possible outcome for the fetus.

DIAGNOSTICS (2021)

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Review Medicine, General & Internal

Pathophysiology of respiratory failure in patients with osteogenesis imperfecta: a systematic review

S. Storoni et al.

Summary: Respiratory failure is a major cause of death in patients with Osteogenesis Imperfecta and can be attributed to both thoracic wall changes and intrinsic collagen alterations in the lung. The findings suggest that pulmonary function disorders in OI may not only be caused by skeletal deformities but also by intrapulmonary defects.

ANNALS OF MEDICINE (2021)

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Article Urology & Nephrology

Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease

Simon R. Walker et al.

Summary: Decreased ATM protein expression is associated with poor outcomes in advanced prostate cancer patients. Assessing the combined status of ATM/PTEN in PCa patients may aid in risk stratification.

EUROPEAN UROLOGY OPEN SCIENCE (2021)

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Article Oncology

Landscape of Biomarkers in Non-small Cell Lung Cancer Using Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry

Richard S. P. Huang et al.

Summary: By combining CGP with PD-L1 IHC, actionable results were obtained for 70.5% of NSCLC patients, with an additional 86.7% potentially eligible for other biomarker-associated therapies or clinical trials. This highlights the improved clinical utility of using both CGP and IHC for expanding biomarker-guided therapeutic options in NSCLC patients.

PATHOLOGY & ONCOLOGY RESEARCH (2021)

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Article Oncology

EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Katherine L. Morel et al.

Summary: Combination of EZH2 inhibition and anti-PD-1 has been shown to enhance antitumor immune responses in prostate cancer by activating the dsRNA-STING-ISG stress response signaling; EZH2 inhibition upregulates genes involved in antigen presentation and interferon response, suggesting it as a therapeutic direction to enhance prostate cancer response to PD-1 CPI.

NATURE CANCER (2021)

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Article Urology & Nephrology

High Serine-arginine Protein Kinase 1 Expression with PTEN Loss Defines Aggressive Phenotype of Prostate Cancer Associated with Lethal Outcome and Decreased Overall Survival

Hatem Abou-Ouf et al.

Summary: SRPK1 expression, combined with PTEN status, plays a significant role in predicting the prognosis of prostate cancer patients. High expression of SRPK1, especially when combined with negative PTEN expression, is associated with worse overall survival and prostate cancer-specific mortality. Combining the status of SRPK1 and PTEN may help in stratifying patients into different prognostic categories.

EUROPEAN UROLOGY OPEN SCIENCE (2021)

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Article Medicine, Research & Experimental

WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer

Qianghua Zhou et al.

Summary: The study revealed that targeting WDR5 suppressed proliferation, enhanced apoptosis, increased chemosensitivity to cisplatin and immunotherapy in prostate cancer. Inhibiting WDR5 could also block the expression of certain genes related to cell cycle, anti-apoptosis, DNA repair, and immune response. Targeting WDR5 with OICR-9429 shows promise as a potent therapy drug to improve the antitumor effect of cisplatin or immunotherapy in prostate cancer.

THERANOSTICS (2021)

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Article Urology & Nephrology

Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study

Tommy Nyberg et al.

EUROPEAN UROLOGY (2020)

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Review Immunology

Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases

Andrea Palicelli

APMIS (2020)

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Review Cell Biology

What do we know about the cytological features of pure intraductal carcinomas of the salivary glands?

Andrea Palicelli

CYTOPATHOLOGY (2020)

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Article Oncology

Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study

Emmanuel S. Antonarakis et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer

Ashley E. Ross et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2020)

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Article Pathology

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. I. Molecular Biomarkers in Prostate Cancer

Tamara L. Lotan et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

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Article Obstetrics & Gynecology

Expression of the Immune Checkpoints LAG-3 and PD-L1 in High-grade Serous Ovarian Carcinoma: Relationship to Tumor-associated Lymphocytes and GermlineBRCAStatus

Rachel Whitehair et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2020)

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Article Oncology

PT-112 in advanced metastatic castrate-resistant prostate cancer (mCRPC), as monotherapy or in combination with PD-L1 inhibitor avelumab: Findings from two phase I studies.

Alan Haruo Bryce et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Pharmacology & Pharmacy

LRP11 activates β-catenin to induce PD-L1 expression in prostate cancer

Sishun Gan et al.

JOURNAL OF DRUG TARGETING (2020)

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Article Biochemistry & Molecular Biology

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

Sangeeta Goswami et al.

NATURE MEDICINE (2020)

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Article Pathology

High homogeneity of mismatch repair deficiency in advanced prostate cancer

Christoph Fraune et al.

VIRCHOWS ARCHIV (2020)

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Article Oncology

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Aleksandar Z. Obradovic et al.

CLINICAL CANCER RESEARCH (2020)

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Article Oncology

PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models

Takahiro Yamazaki et al.

ONCOIMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Mismatch repair deficiency in metastatic prostate cancer: Response to PD-1 blockade and standard therapies

Laura S. Graham et al.

PLOS ONE (2020)

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Article Medicine, Research & Experimental

Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer

Stephen T. Ryan et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Urology & Nephrology

MP51-12 ELL2 DEFICIENCY UPREGULATES PD-L1 EXPRESSION VIA JAK2 SIGNALING IN PROSTATE CANCER CELLS

Hui Ding* et al.

JOURNAL OF UROLOGY (2020)

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Article Oncology

Tumor Fusion Burden as a Hallmark of Immune Infiltration in Prostate Cancer

Marie-Claire Wagle et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Article Medicine, General & Internal

Loss of DNA mismatch repair proteins in prostate cancer

Meenal Sharma et al.

MEDICINE (2020)

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Article Oncology

Neoadjuvant PROSTVAC prior to radical prostatectomy enhances T-cell infiltration into the tumor immune microenvironment in men with prostate cancer

Houssein Abdul Sater et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Medicine, General & Internal

Olaparib for Metastatic Castration-Resistant Prostate Cancer

J. de Bono et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer

Jinghui Liu et al.

ONCOGENE (2020)

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Article Oncology

Chemerin Reactivates PTEN and Suppresses PD-L1 in Tumor Cells via Modulation of a Novel CMKLR1-mediated Signaling Cascade

Keith Rennier et al.

CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

Yiannis Philippou et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Genetics & Heredity

A four-gene signature in the tumor microenvironment that significantly associates with the prognosis of patients with breast cancer

Jianxin Wang et al.

GENE (2020)

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Article Oncology

A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone

Julie N. Graff et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Medicine, General & Internal

Endometrial Carcinomas with Intestinal-Type Metaplasia/Differentiation: Does Mismatch Repair System Defects Matter? Case Report and Systematic Review of the Literature

Laura Ardighieri et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA

Yu Wu et al.

BIOCHEMICAL JOURNAL (2020)

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Article Oncology

Wee1 kinase inhibitor AZD1775 potentiates CD8+T cell-dependent antitumour activity via dendritic cell activation following a single high dose of irradiation

Bin Wang et al.

MEDICAL ONCOLOGY (2020)

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Article Oncology

Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial

Padmanee Sharma et al.

CANCER CELL (2020)

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Article Oncology

LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

Qi-Hua Chen et al.

CANCER CELL INTERNATIONAL (2020)

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Article Biotechnology & Applied Microbiology

Novel Long Non-coding RNA lncAMPC Promotes Metastasis and Immunosuppression in Prostate Cancer by Stimulating LIF/LIFR Expression

Wei Zhang et al.

MOLECULAR THERAPY (2020)

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Article Oncology

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration

Wassim Abida et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers

Junnian Wei et al.

MOLECULAR IMAGING AND BIOLOGY (2020)

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Review Multidisciplinary Sciences

Revisiting the PD-1 pathway

Nikolaos Patsoukis et al.

SCIENCE ADVANCES (2020)

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Article Medicine, General & Internal

Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations

Sabine Schmid et al.

JAMA NETWORK OPEN (2020)

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Article Oncology

Dramatic response to combination pembrolizumab and radiation in metastatic castration resistant prostate cancer

Harry J. Han et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

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Article Oncology

Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer

Xinji Zhang et al.

JOURNAL OF CANCER (2020)

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Article Immunology

Targeting Prostate Cancer Using Intratumoral Cytotopically Modified Interleukin-15 Immunotherapy in a Syngeneic Murine Model

Efthymia Papaevangelou et al.

IMMUNOTARGETS AND THERAPY (2020)

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Article Oncology

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

Jacob J. Orme et al.

ONCOIMMUNOLOGY (2020)

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Article Oncology

CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors

Emmanuel S. Antonarakis et al.

JCO PRECISION ONCOLOGY (2020)

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Article Medicine, Research & Experimental

Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity

Bo Wang et al.

THERANOSTICS (2020)

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Article Oncology

The Immune Landscape of Prostate Cancer and Nomination of PD-L2 as a Potential Therapeutic Target

Shuang G. Zhao et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

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Article Biochemistry & Molecular Biology

MLL3 enhances the transcription of PD-L1 and regulates anti-tumor immunity

Wei Xiong et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Article Oncology

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors

Kyung Hae Jung et al.

CLINICAL CANCER RESEARCH (2019)

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Article Oncology

Programmed death ligand 1 expression in prostate cancer cells is associated with deep changes of the tumor inflammatory infiltrate composition

Manuel Scimeca et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2019)

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Article Oncology

Prevalence of Germline Variants in Prostate Cancer and Implications for Current Genetic Testing Guidelines

Piper Nicolosi et al.

JAMA ONCOLOGY (2019)

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Article Immunology

PD-L1 expression and deficient mismatch repair in ductal adenocarcinoma of the prostate

Claes Lindh et al.

APMIS (2019)

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Article Cell Biology

JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression

Kaisheng Liu et al.

CELL BIOLOGY INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Reduced T-cell Numbers and Elevated Levels of Immunomodulatory Cytokines in Metastatic Prostate Cancer Patients De Novo Resistant to Abiraterone and/or Enzalutamide Therapy

Sumanta K. Pal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

PD-L1 Expression in De Novo Metastatic Castration-sensitive Prostate Cancer

Roberto Iacovelli et al.

JOURNAL OF IMMUNOTHERAPY (2019)

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Article Multidisciplinary Sciences

Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer

E. Richardsen et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer

Matthew D. Tucker et al.

CANCER MEDICINE (2019)

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Article Cell Biology

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression

Qixia Xu et al.

AGING CELL (2019)

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Article Medicine, General & Internal

Immunohistochemistry of immune checkpoint markers PD-1 and PD-L1 in prostate cancer

Meenal Sharma et al.

MEDICINE (2019)

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Article Oncology

CTHRC1 and PD-1/PD-L1 expression predicts tumor recurrence in prostate cancer

Qing Zhou et al.

MOLECULAR MEDICINE REPORTS (2019)

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Article Cell Biology

The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer

Marina Kazantseva et al.

CELL DEATH & DISEASE (2019)

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Article Oncology

Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Stephanie O. Dudzinski et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Oncology

LBA50Pre-specified interim analysis of GALAHAD: A phase II study of niraparib in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and biallelic DNA-repair gene defects (DRD)

M R Smith et al.

ANNALS OF ONCOLOGY (2019)

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Article Oncology

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Huiying Han et al.

CANCER CELL (2019)

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Review Biochemistry & Molecular Biology

Mechanisms Controlling PD-L1 Expression in Cancer

Jong-Ho Cha et al.

MOLECULAR CELL (2019)

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Article Chemistry, Multidisciplinary

Sequential MR Image-Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy

Bongseo Choi et al.

SMALL (2019)

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Article Respiratory System

A tricky and rare cause of pulmonary eosinophilia: myeloid/lymphoid neoplasm with eosinophilia and rearrangement of PDGFRA

Magda Zanelli et al.

BMC PULMONARY MEDICINE (2019)

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Article Oncology

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition

Wendy Mao et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Oncology

Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients

Claire L. Ihle et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Biotechnology & Applied Microbiology

Overexpression of SOCS3 mediated by adenovirus vector in mouse and human castration-resistant prostate cancer cells increases the sensitivity to NK cells in vitro and in vivo

Tomomi Yoneda et al.

CANCER GENE THERAPY (2019)

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Article Oncology

Programmed Death Ligand 1 (PD-L1) Status and Tumor-Infiltrating Lymphocytes in Hot Spots of Primary and Liver Metastases in Prostate Cancer With Neuroendocrine Differentiation

Jost von Hardenberg et al.

CLINICAL GENITOURINARY CANCER (2019)

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Article Urology & Nephrology

Clinical Features and Therapeutic Outcomes in Men with Advanced Prostate Cancer and DNA Mismatch Repair Gene Mutations

Emmanuel S. Antonarakis et al.

EUROPEAN UROLOGY (2019)

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Article Oncology

Expression of PD-L1 in tumor-associated nerves correlates with reduced CD8+ tumor-associated lymphocytes and poor prognosis in prostate cancer

Ru-Jun Mo et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Article Oncology

PROREPAIR-B: A Prospective Cohort Study of the Impact of Germline DNA Repair Mutations on the Outcomes of Patients With Metastatic Castration-Resistant Prostate Cancer

Elena Castro et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

Xin Jin et al.

MOLECULAR CELL (2019)

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Review Pathology

Pregnancy-related decidualization of subcutaneous endometriosis occurring in a post-caesarean section scar: Case study and review of the literature

Cinzia D'Agostino et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Article Endocrinology & Metabolism

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Timothy E. Krueger et al.

PROSTATE (2019)

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Article Endocrinology & Metabolism

Identification of targets for prostate cancer immunotherapy

Antonios Papanicolau-Sengos et al.

PROSTATE (2019)

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Article Biochemistry & Molecular Biology

Specific zinc finger-induced methylation of PD-L1 promoter inhibits its expression

Xue Li et al.

FEBS OPEN BIO (2019)

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Article Oncology

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

Wassim Abida et al.

JAMA ONCOLOGY (2019)

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Article Urology & Nephrology

PD-L1 Expression and CD8+ T-cell Infiltrate are Associated with Clinical Progression in Patients with Node-positive Prostate Cancer

Florent Petitprez et al.

EUROPEAN UROLOGY FOCUS (2019)

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Article Biochemistry & Molecular Biology

The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer

Naijin Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Pathology

Role of ERCC1 expression in colorectal adenoma-carcinoma sequence and relation to other mismatch repair proteins expression, clinicopathological features and prognosis in mucinous and non-mucinous colorectal carcinoma

Abd AlRahman Mohammad Foda et al.

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY (2019)

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Article Oncology

The prognostic value of tumor PD-L1 status in patients with metastatic prostate cancer

V. B. Matveev et al.

ONKOUROLOGIYA (2019)

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Article Oncology

The Immune Checkpoint Regulator PDL1 is an Independent Prognostic Biomarker for Biochemical Recurrence in Prostate Cancer Patients Following Adjuvant Hormonal Therapy

Heng Li et al.

JOURNAL OF CANCER (2019)

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Article Oncology

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1

Christina M. Maher et al.

MOLECULAR CANCER RESEARCH (2018)

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Article Multidisciplinary Sciences

Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance

Jinfang Zhang et al.

NATURE (2018)

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Review Oncology

The molecular biology of prostate cancer: current understanding and clinical implications

Jason Gandhi et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2018)

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Article Pathology

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

Michael C. Haffner et al.

AMERICAN JOURNAL OF PATHOLOGY (2018)

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Article Chemistry, Analytical

Molecular Profiling of Pooled Circulating Tumor Cells from Prostate Cancer Patients Using a Dual-Antibody-Functionalized Microfluidic Device

Changqing Yin et al.

ANALYTICAL CHEMISTRY (2018)

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Article Oncology

Pembrolizumab for advanced prostate adenocarcinoma: findings of the KEYNOTE-028 study

A. R. Hansen et al.

ANNALS OF ONCOLOGY (2018)

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Review Immunology

Paratesticular seminoma: echographic features and histological diagnosis with review of the literature

Andrea Palicelli et al.

APMIS (2018)

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Article Biochemistry & Molecular Biology

Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types

Toshiyuki Ishiba et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Cell Biology

MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the Tumor Microenvironment by Blocking the PD-L1 Immune Checkpoint

Zhen Tao et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Oncology

In vitro-induced M2 type macrophages induces the resistance of prostate cancer cells to cytotoxic action of NK cells

Lijun Xu et al.

EXPERIMENTAL CELL RESEARCH (2018)

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Article Oncology

Combined inhibition of JAK1,2/Stat3-PD-L1 signaling pathway suppresses the immune escape of castration-resistant prostate cancer to NK cells in hypoxia

Li-Jun Xu et al.

MOLECULAR MEDICINE REPORTS (2018)

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Article Oncology

ATM-JAK-PD-L1 signaling pathway inhibition decreases EMT and metastasis of androgen-independent prostate cancer

Lan Zhang et al.

MOLECULAR MEDICINE REPORTS (2018)

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Article Oncology

Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels

Lijun Xu et al.

MOLECULAR ONCOLOGY (2018)

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Article Endocrinology & Metabolism

Adipocytes affect castration-resistant prostate cancer cells to develop the resistance to cytotoxic action of NK cells with alterations of PD-L1/NKG2D ligand levels in tumor cells

Lijun Xu et al.

PROSTATE (2018)

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Article Oncology

Abiraterone–Olaparib Combo Aids Men with mCRPC

Cancer Discovery (2018)

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Article

Concurrent, but not sequential, PD-1 blockade with a DNA vaccine elicits anti-tumor responses in patients with metastatic, castration-resistant prostate cancer

Douglas G. McNeel et al.

Oncotarget (2018)

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Article Oncology

RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer

Elizabeth Ahern et al.

ONCOIMMUNOLOGY (2018)

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Review Immunology

Unicystic high-grade intraductal carcinoma of the parotid gland: cytological and histological description with clinic-pathologic review of the literature

Andrea Palicelli et al.

APMIS (2018)

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Article Pathology

Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types

Chiyun Wang et al.

HUMAN PATHOLOGY (2018)

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Article Medicine, Research & Experimental

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

Daniel Nava Rodrigues et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Meeting Abstract Oncology

KEYNOTE-199: Pembrolizumab (pembro) for docetaxel-refractory metastatic castration-resistant prostate cancer (mCRPC).

Johann S. De Bono et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Pathology

Immune infiltrates and PD-L1 expression in treatment-naive acinar prostatic adenocarcinoma: an exploratory analysis

Elan Hahn et al.

JOURNAL OF CLINICAL PATHOLOGY (2018)

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Article Oncology

Quick efficacy seeking trial (QuEST1): a novel combination immunotherapy study designed for rapid clinical signal assessment metastatic castration-resistant prostate cancer

Jason M. Redman et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Article Oncology

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers

Dayson Moreira et al.

CLINICAL CANCER RESEARCH (2018)

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Article Multidisciplinary Sciences

Cancer immunotherapy using PolyPurine Reverse Hoogsteen hairpins targeting the PD-1/PD-L1 pathway in human tumor cells

Miriam Marlene Medina Enriquez et al.

PLOS ONE (2018)

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Article Oncology

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

Fatima Karzai et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Article Oncology

Immunotherapy utilizing the combination of natural killer- and antibody dependent cellular cytotoxicity (ADCC)-mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

Kathleen E. Fenerty et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Article Urology & Nephrology

Positive Pelvic Lymph Nodes in Prostate Cancer Harbor Immune Suppressor Cells To Impair Tumor-reactive T Cells

Vidit Sharma et al.

EUROPEAN UROLOGY FOCUS (2018)

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Article Biochemical Research Methods

Imaging PD-L1 Expression with ImmunoPET

Charles Truillet et al.

BIOCONJUGATE CHEMISTRY (2018)

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Article Biotechnology & Applied Microbiology

Carcinosarcoma of the prostate: case report with molecular and histological characterization

Samanta Salvi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2018)

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Article Oncology

Immunogenomics: A Negative Prostate Cancer Outcome Associated with TcR-γ/δ Recombinations

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Article Oncology

PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)

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Article Immunology

Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells

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IMMUNOLOGY LETTERS (2017)

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Effective combinatorial immunotherapy for castration-resistant prostate cancer

Xin Lu et al.

NATURE (2017)

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Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

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NATURE MEDICINE (2017)

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Article Biochemistry & Molecular Biology

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

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NATURE MEDICINE (2017)

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Article Oncology

SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells

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ONCOTARGET (2017)

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5T4 oncofoetal glycoprotein: an old target for a novel prostate cancer immunotherapy

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The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort

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Comprehensive immunohistochemical analysis of PD-L1 shows scarce expression in castration-resistant prostate cancer

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Sensitive detection of PD-L1 expression on circulating epithelial tumor cells (CETCs) could be a potential biomarker to select patients for treatment with PD-1/PD-L1 inhibitors in early and metastatic solid tumors

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THERANOSTICS (2017)

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Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade

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Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

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Article Oncology

PD-1/PD-L1 blockade enhances the efficacy of SA-GM-CSF surface-modified tumor vaccine in prostate cancer

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Expression of PD-L1 in Hormone-naive and Treated Prostate Cancer Patients Receiving Neoadjuvant Abiraterone Acetate plus Prednisone and Leuprolide

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Immune Characterization of the Programmed Death Receptor Pathway in High Risk Prostate Cancer

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The association between germline BRCA2 variants and sensitivity to platinum-based chemotherapy among men with metastatic prostate cancer

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A unique case of bilateral ovarian splenosis and review of the literature

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Meeting Abstract Oncology

PD-L1 blockade in preclinical models of PTEN-deficient prostate cancer

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Armed Oncolytic Adenovirus-Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors

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Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

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Article Oncology

The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer

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Article Oncology

Magnitude of PD-1, PD-L1 and T Lymphocyte Expression on Tissue from Castration-Resistant Prostate Adenocarcinoma: An Exploratory Analysis

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Review Medicine, General & Internal

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Tungiasis in Italy: An imported case of Tunga penetrans and review of the literature

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Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate

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ONCOTARGET (2016)

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CXCL12 promoter methylation and PD-L1 expression as prognostic biomarkers in prostate cancer patients

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ONCOTARGET (2016)

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Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN-deficient prostate cancer

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Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

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Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer

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PD-L1 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy

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ONCOTARGET (2016)

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Antitumor vaccination of prostate cancer patients elicits PD-1/PD-L1 regulated antigen-specific immune responses

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Potential role of nuclear PD-L1 expression in cell-surface vimentin positive circulating tumor cells as a prognostic marker in cancer patients

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Integrative Clinical Genomics of Advanced Prostate Cancer

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The Molecular Taxonomy of Primary Prostate Cancer

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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

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Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance

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IL-27 induces the expression of IDO and PD-L1 in human cancer cells

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PD-L1 is highly expressed in Enzalutamide resistant prostate cancer

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Radiation-Induced Modulation of Costimulatory and Coinhibitory T-Cell Signaling Molecules on Human Prostate Carcinoma Cells Promotes Productive Antitumor Immune Interactions

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Review Cell Biology

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Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti-PD-1 Therapy

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Langer Mesomelic Dysplasia in Early Fetuses: Two Cases and a Literature Review

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TMPRSS2-ERG Expression Predicts Prostate Cancer Survival and Associates with Stromal Biomarkers

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Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

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Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+ PD-L1+ phenotype in prostate cancer

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Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

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Article Oncology

Elevated Risk of Prostate Cancer Among Men With Lynch Syndrome

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Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant Metastasis, and Poor Survival Outcomes in Prostate Cancer

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Review Andrology

The role of BRCA1 and BRCA2 in prostate cancer

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ASIAN JOURNAL OF ANDROLOGY (2012)

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Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

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CANCER RESEARCH (2012)

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p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3

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PD-1 Blockade Augments Th1 and Th17 and Suppresses Th2 Responses in Peripheral Blood From Patients With Prostate and Advanced Melanoma Cancer

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Article Oncology

Risks of Primary Extracolonic Cancers Following Colorectal Cancer in Lynch Syndrome

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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)

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Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

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Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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BRCA1 and BRCA2: different roles in a common pathway of genome protection

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NATURE REVIEWS CANCER (2012)

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E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

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ANNALS OF INTERNAL MEDICINE (2009)

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Letter Multidisciplinary Sciences

ETS rearrangements and prostate cancer initiation

Brett S. Carver et al.

NATURE (2009)

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Review Medicine, General & Internal

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

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Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9

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CANCER SCIENCE (2008)

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Recurrent gene fusions in prostate cancer

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NATURE REVIEWS CANCER (2008)

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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

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NATURE MEDICINE (2007)

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Review Oncology

The DNA damage response arouses the immune system

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CANCER RESEARCH (2006)

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Number of published systematic reviews and global burden of disease: database analysis

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BRITISH MEDICAL JOURNAL (2003)

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What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review (Part 6): Correlation of PD-L1 Expression with the Status of Mismatch Repair System, BRCA, PTEN, and Other Genes

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