4.7 Article

WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency

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DAKS1, a Kunitz Scaffold Peptide from the Venom Gland of Deinagkistrodon acutus Prevents Carotid-Artery and Middle-Cerebral-Artery Thrombosis via Targeting Factor XIa

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Summary: SBPs derived from Deinagkistrodon acutus venom gland, particularly DAKS1, have shown promising anticoagulant and antithrombotic effects, without significant bleeding risk, suggesting their potential for drug development in treating thrombosis and stroke disorders.

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