期刊
BIOMEDICINES
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines9101381
关键词
antimicrobial; peptide; conjugate; nanoparticle; delivery system
资金
- German Federal Ministry of Education and Research (BMBF) project [DLR CUB 17WTZ-014/01DN18009]
- German Research Society (DFG) from Ulm University, Germany [CRC1279]
- Alexander von Humboldt-Stiftung, Research Group Linkage Program [1160914]
- DAAD (Bonn, Germany)
- German Federal Foreign Ministry [57592717]
Antimicrobial peptides (AMPs) are structurally diverse molecules produced by multicellular organisms as a first line of defense against pathogens. AMPs, also known as host defense peptides in higher eukaryotic organisms, display immunomodulatory and anticancer activities. Challenges such as proteolytic digestion and cytotoxicity have prompted the development of strategies to improve the properties of AMPs for effective therapeutic use.
Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally diverse molecules are produced as the first line of defense against pathogens such as bacteria, viruses, fungi, and parasites. Also known as host defense peptides in higher eukaryotic organisms, AMPs display immunomodulatory and anticancer activities. During the last 30 years, technological advances have boosted the research on antimicrobial peptides, which have also attracted great interest as an alternative to tackling the antimicrobial resistance scenario mainly provoked by some bacterial and fungal pathogens. However, the introduction of natural AMPs in clinical trials faces challenges such as proteolytic digestion, short half-lives, and cytotoxicity upon systemic and oral application. Therefore, some strategies have been implemented to improve the properties of AMPs aiming to be used as effective therapeutic agents. In the present review, we summarize the discovery path of AMPs, focusing on preclinical development, recent advances in chemical optimization and peptide delivery systems, and their introduction into the market.
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