Spectrum of Clinical Research in Juvenile Idiopathic Arthritis: A Cross-Sectional Analysis of Registered Studies in Clinicaltrials.gov and Clinicaltrialsregister.eu

Article Pharmacology & Pharmacy

Response Similarity Assessment Between Polyarticular Juvenile Idiopathic Arthritis and Adult Rheumatoid Arthritis for Biologics

Renu Singh et al.

Summary: This study aimed to compare the extrapolation of efficacy between pJIA and RA, with findings indicating that in the majority of cases, pJIA response was similar or higher compared to RA trials.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Review Pediatrics

Growth and puberty in children with juvenile idiopathic arthritis

Debora Mariarita d'Angelo et al.

Summary: Juvenile Idiopathic Arthritis is a common chronic disease in children, often leading to growth and puberty disorders that can cause short stature or limb asymmetry. Various factors, including chronic inflammation, medication, undernutrition, and delayed puberty, can contribute to these disorders, highlighting the importance of early assessment and intervention.

PEDIATRIC RHEUMATOLOGY (2021)

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Review Pharmacology & Pharmacy

Biomarkers of Response to Biologic Therapy in Juvenile Idiopathic Arthritis

Varvara Choida et al.

Summary: This study evaluated the role of biomarkers in predicting and assessing biologic treatment response and clinical remission in JIA, proposing new strategies for biomarker use. Various types of biomarkers were reviewed, identifying candidates with potential clinical utility and highlighting the need for new biomarker discovery and improved clinical applications.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

Krzysztof Orczyk et al.

Summary: MicroRNAs, small noncoding sequences of ribonucleic acid, function as posttranscriptional regulators of gene expression. The study aims to explore the potential of microRNAs as biomarkers for diagnosing and monitoring juvenile idiopathic arthritis (JIA) patients, focusing on commonly studied sequences like miR-16, miR-125a-5p, miR-146a, miR-155, and miR-223. It also discusses challenges in using microRNAs in pediatric rheumatology, such as biomarker specificity and measurements involving synovial fluid.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Review Medicine, General & Internal

Comprehensive Management of Rheumatic Diseases Affecting the Temporomandibular Joint

Lauren Covert et al.

Summary: The article emphasizes the impact of rheumatic conditions on the temporomandibular joint, outlining the importance of medical and surgical management in these patients, as well as highlighting the necessity for ongoing patient reassessment and monitoring.

DIAGNOSTICS (2021)

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Article Psychology, Developmental

Improving Adolescent and Young Adult Engagement in the Process of Transitioning to Adult Care

Lisa Lestishock et al.

Summary: The purpose of this project was to improve engagement of adolescents and young adults, as well as parents/caregivers, in the process of transitioning from pediatric to adult care using clinical readiness assessment tools and the Institute for Healthcare Improvement Model. Results showed improved readiness assessment scores among participants, as well as some improvements in the implementation of transition policies at the public health center, although patient portal enrollment did not meet the expected goal.

JOURNAL OF ADOLESCENT HEALTH (2021)

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Article Rheumatology

Transition Readiness in Adolescents With Juvenile Idiopathic Arthritis and Childhood-Onset Systemic Lupus Erythematosus

Jeanine McColl et al.

Summary: The study found a significant association between age and transition readiness, with readiness increasing with patient age. There is significant variability in Transition-Q scores between patients of the same age, suggesting the need for an individualized approach to improving self-management skills.

ACR OPEN RHEUMATOLOGY (2021)

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Review Rheumatology

Current Therapeutic Options for the Treatment of Juvenile Idiopathic Arthritis

Ioanna G. Saougou et al.

Summary: Juvenile idiopathic arthritis [JIA] is a chronic inflammatory disease that affects children under the age of 16 and has seen significant advancements in treatment, particularly with the introduction of biologic therapies. These treatments have revolutionized the management of JIA by preserving functional activity, controlling pain, and preventing joint damage. Additionally, international guidelines from institutions like the American College of Rheumatology have further improved the outcomes for patients with JIA.

CURRENT RHEUMATOLOGY REVIEWS (2021)

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Article Rheumatology