期刊
BIOMEDICINES
卷 9, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines9111730
关键词
Creutzfeldt-Jakob disease; SARS-CoV-2; accelerated neurodegeneration; aging
资金
- National Institute on Aging [R01AG-064003, K02AG-068595]
This study describes a case of an elderly female patient with Creutzfeldt-Jakob disease (CJD) who experienced clinical deterioration and neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the disease progression, a poor outcome was observed. The report suggests a vulnerability to CJD and increased CJD progression following COVID-19, indicating age-dependent neurological effects of SARS-CoV-2 infection.
Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt-Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the progression of the disease, a dismal outcome ensued. This report further evidences the age-dependent neurological effects of SARS-CoV-2 infection and proposes a vulnerability to CJD and increased CJD progression following COVID-19.
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