期刊
BIOMARKER RESEARCH
卷 9, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40364-021-00348-y
关键词
Liquid biopsy; Immunotherapy; Immune checkpoint inhibitors; Hepatocellular carcinoma; ctDNA; CTC
资金
- National Key R&D Program of China [2019YFC1315800, 2019YFC1315802]
- National Natural Science Foundation of China [82150004, 81830102, 81772578, 81802991]
- Fudan University [IDF152064/014]
- Zhongshan Hospital Fudan University [2021ZSYQ09]
- Shanghai Municipal Key Clinical Specialty
Immunotherapy, particularly immune checkpoint inhibitors, has made significant progress in the management of hepatocellular carcinoma (HCC), but the challenge of identifying the optimal responders to ICIs treatment and monitoring treatment effects in a timely manner remains. Liquid biopsy may offer a promising approach to address tumor heterogeneity, identify patients who respond to immunotherapy, monitor treatment effects, and uncover resistance mechanisms.
The past years have witnessed the vigorous development of immunotherapy, mainly immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (PD-1) protein and its ligand, PD-L1, and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4). Indeed, ICIs have largely revolutionized the management and improved the prognosis of patients with intermediate and advanced hepatocellular carcinoma (HCC). However, biomarker-based stratification of HCC patients for optimal response to ICI treatment is still of unmet need and again, there exists the necessity to dynamically monitor treatment effect in real-time manner. The role of conventional biomarkers in immunotherapy surveillance is largely limited by spatial and temporal tumor heterogeneity whereas liquid biopsy seems to be promising to circumvent tumor heterogeneity to identify candidate patients who may response to immunotherapy, to dynamically monitor treatment effect and to unveil resistance mechanism. Herein, we provide a thorough review about the potential utility of liquid biopsy in immunotherapy for HCC and discuss its future perspectives.
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