期刊
BIOMARKER RESEARCH
卷 9, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40364-021-00314-8
关键词
Immune checkpoint inhibitor; Immune-related adverse events; Mechanism; Risk factor
资金
- National Natural Science Foundation of China [81702292]
This review explores the potential mechanisms of immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) and summarizes the existing evidence on risk factors associated with their occurrence. It particularly focuses on the impact of clinicopathological and demographic factors on the risk of irAEs.
Immune checkpoint inhibitors (ICIs) have heralded the advent of a new era in oncology by holding the promise of prolonged survival in severe and otherwise treatment-refractory advanced cancers. However, the remarkable antitumor efficacy of these agents is overshadowed by their potential for inducing autoimmune toxic effects, collectively termed immune-related adverse events (irAEs). These autoimmune adverse effects are often difficult to predict, possibly permanent, and occasionally fatal. Hence, the identification of risk factors for irAEs is urgently needed to allow for prompt therapeutic intervention. This review discusses the potential mechanisms through which irAEs arise and summarizes the existing evidence regarding risk factors associated with the occurrence of irAEs. In particular, we examined available data regarding the effect of a series of clinicopathological and demographic factors on the risk of irAEs.
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