期刊
JOURNAL OF INFLAMMATION RESEARCH
卷 14, 期 -, 页码 5475-5487出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S329697
关键词
cytokines; coronavirus pneumonia; cytokine storm; immune evasion; interferon
类别
资金
- National Natural Science Foundation of China [81860719]
- Xizang Science and Technology Department
- COVID-19 Epidemics Emergency Project of Xizang Minzu University [XZMDYJ04]
Cytokine storm is a major cause of death in patients with severe coronavirus pneumonia, characterized by excessive immune-inflammatory reaction. By comparing the cytokine storms caused by different coronaviruses, potential mechanisms for guiding future clinical treatment can be identified.
Cytokine storm (CS) is a significant cause of death in patients with severe coronavirus pneumonia. Excessive immune-inflammatory reaction, many inflammatory cell infiltration, and extreme increase of proinflammatory cytokines and chemokines lead to acute lung injury and acute respiratory distress syndrome (ARDS). This review compares the characters of cytokine storms and immune responses caused by three highly pathogenic and infectious coronaviruses (HCoVs), including severe acute respiratory syndrome corona virus (SARS-CoV), Middle East respiratory syndrome-coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyzes the possible mechanisms to guide clinical treatment in the future.
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