4.6 Review

Comparison of the Characteristics of Cytokine Storm and Immune Response Induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections

期刊

JOURNAL OF INFLAMMATION RESEARCH
卷 14, 期 -, 页码 5475-5487

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S329697

关键词

cytokines; coronavirus pneumonia; cytokine storm; immune evasion; interferon

资金

  1. National Natural Science Foundation of China [81860719]
  2. Xizang Science and Technology Department
  3. COVID-19 Epidemics Emergency Project of Xizang Minzu University [XZMDYJ04]

向作者/读者索取更多资源

Cytokine storm is a major cause of death in patients with severe coronavirus pneumonia, characterized by excessive immune-inflammatory reaction. By comparing the cytokine storms caused by different coronaviruses, potential mechanisms for guiding future clinical treatment can be identified.
Cytokine storm (CS) is a significant cause of death in patients with severe coronavirus pneumonia. Excessive immune-inflammatory reaction, many inflammatory cell infiltration, and extreme increase of proinflammatory cytokines and chemokines lead to acute lung injury and acute respiratory distress syndrome (ARDS). This review compares the characters of cytokine storms and immune responses caused by three highly pathogenic and infectious coronaviruses (HCoVs), including severe acute respiratory syndrome corona virus (SARS-CoV), Middle East respiratory syndrome-coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyzes the possible mechanisms to guide clinical treatment in the future.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据