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Companion Tumor Sequencing to Assess the Clinical Significance of Germline Sequencing in Children With Cancer

JAMA NETWORK OPEN (2021)

Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors

Elise M. Fiala et al.

Summary: This study reported the results of prospective DNA sequencing in pediatric solid tumor patients, identifying germline variants associated with high and moderate penetrance genes, some of which were unexpected. Most patients with positive results underwent clinical genetics consultation, and some relatives also underwent cascade testing.

NATURE CANCER (2021)

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Editorial Material Oncology

BRCA1 Versus BRCA2 and PARP Inhibitor Sensitivity in Prostate Cancer: More Different Than Alike?

Mark C. Markowski et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Genetics & Heredity

Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high frequency of cancer prone syndromes

Anna Byrjalsen et al.

PLOS GENETICS (2020)

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Article Oncology

Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome: Bringing Resolution to the Diagnostic Process

Monalyn U. Salvador et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Review Biochemistry & Molecular Biology

Epidemiology and genetics of childhood cancer

CA Stiller

ONCOGENE (2004)

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Companion Tumor Sequencing to Assess the Clinical Significance of Germline Sequencing in Children With Cancer

相关参考文献

Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors

BRCA1 Versus BRCA2 and PARP Inhibitor Sensitivity in Prostate Cancer: More Different Than Alike?

Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high frequency of cancer prone syndromes

Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome: Bringing Resolution to the Diagnostic Process

Epidemiology and genetics of childhood cancer

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