期刊
NPJ REGENERATIVE MEDICINE
卷 7, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41536-021-00203-6
关键词
-
资金
- Regenerative Medicine Crossing Borders (RegMed XB)
- Dutch Ministry of Economic Affairs
- Dutch Arthritis Foundation [LLP-12, LLP-22]
- ZonMw (Netherlands Organization for Health Research and Development) of the University Medical Center Utrecht
- strategic theme Regenerative Medicine & Stem Cells of the University Medical Center Utrecht
- European Research Council [949806]
- Horizon 2020 Research and Innovation Program [814444]
- European Research Council (ERC) [949806] Funding Source: European Research Council (ERC)
This systematic review summarizes the latest research on endogenous progenitor cells in adult articular cartilage. These progenitor cells, called articular cartilage-derived progenitor cells (ACPCs), can be isolated from cartilage of various species including humans, horses, and cows. ACPCs possess mesenchymal stromal cell (MSC)-like characteristics and show no signs of hypertrophic differentiation, making them promising for cartilage repair. However, there is currently no established unique cell marker for identifying ACPCs, leading to variations in isolation and characterization protocols.
Over the past two decades, evidence has emerged for the existence of a distinct population of endogenous progenitor cells in adult articular cartilage, predominantly referred to as articular cartilage-derived progenitor cells (ACPCs). This progenitor population can be isolated from articular cartilage of a broad range of species, including human, equine, and bovine cartilage. In vitro, ACPCs possess mesenchymal stromal cell (MSC)-like characteristics, such as colony forming potential, extensive proliferation, and multilineage potential. Contrary to bone marrow-derived MSCs, ACPCs exhibit no signs of hypertrophic differentiation and therefore hold potential for cartilage repair. As no unique cell marker or marker set has been established to specifically identify ACPCs, isolation and characterization protocols vary greatly. This systematic review summarizes the state-of-the-art research on this promising cell type for use in cartilage repair therapies. It provides an overview of the available literature on endogenous progenitor cells in adult articular cartilage and specifically compares identification of these cell populations in healthy and osteoarthritic (OA) cartilage, isolation procedures, in vitro characterization, and advantages over other cell types used for cartilage repair. The methods for the systematic review were prospectively registered in PROSPERO (CRD42020184775).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据