期刊
INTERNATIONAL JOURNAL OF HUMAN GENETICS
卷 16, 期 1-2, 页码 53-60出版社
KAMLA-RAJ ENTERPRISES
DOI: 10.1080/09723757.2016.11886278
关键词
Biogenesis; Brain; Distribution; Function; piRNA
资金
- NIH [K01 DA029643, R21 AA021380, R21 AA023237, R21 AA020319]
- ABMRF/The Foundation for Alcohol Research grant award
Piwi-interacting RNAs (piRNAs) are the non-coding RNAs with 24-32 nucleotides (nt). They exhibit stark differences in length, expression pattern, abundance, and genomic organization when compared to micro-RNAs (miRNAs). There are hundreds of thousands unique piRNA sequences in each species. Numerous piRNAs have been identified and deposited in public databases. Since the piRNAs were originally discovered and well-studied in the germline, a few other studies have reported the presence of piRNAs in somatic cells including neurons. This paper reviewed the common features, biogenesis, functions, and distributions of piRNAs and summarized their specific functions in the brain. This review may provide new insights and research direction for brain disorders.
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