期刊
NEUROBIOLOGY OF STRESS
卷 15, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2021.100385
关键词
Socioeconomic position; Neighborhood disadvantage; Structural fMRI; Functional fMRI; Emotion regulation
资金
- National Institute of Mental Health [R01 MH106574]
- National Center for Advancing Translational Sciences, National Institutes of Health [2UL1TR001436, 2TL1TR001437]
This study investigated the impact of neighborhood disadvantage, acute post-traumatic stress symptoms, and individual socioeconomic position on brain structure and functional connectivity. Findings revealed that living in a disadvantaged neighborhood can have negative effects on certain brain regions and functional connectivity, particularly those involved in processing and regulating emotions.
Nearly 14 percent of Americans live in a socioeconomically disadvantaged neighborhood. Lower individual socioeconomic position (iSEP) has been linked to increased exposure to trauma and stress, as well as to alterations in brain structure and function; however, the neural effects of neighborhood SEP (nSEP) factors, such as neighborhood disadvantage, are unclear. Using a multi-modal approach with participants who recently experienced a traumatic injury (N = 185), we investigated the impact of neighborhood disadvantage, acute post-traumatic stress symptoms, and iSEP on brain structure and functional connectivity at rest. After controlling for iSEP, demographic variables, and acute PTSD symptoms, nSEP was associated with decreased volume and alterations of resting-state functional connectivity in structures implicated in affective processing, including the insula, ventromedial prefrontal cortex, amygdala, and hippocampus. Even in individuals who have recently experienced a traumatic injury, and after accounting for iSEP, the impact of living in a disadvantaged neighborhood is apparent, particularly in brain regions critical for experiencing and regulating emotion. These results should inform future research investigating how various levels of socioeconomic circumstances may impact recovery after a traumatic injury as well as policies and community-developed interventions aimed at reducing the impact of socioeconomic stressors.
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