期刊
NEUROBIOLOGY OF STRESS
卷 15, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2021.100393
关键词
Stress disorders; Traumatic; Genetics; Systems biology; Transcriptome; Epigenomics
资金
- NIMH [R21MH121909]
- SPARED Center Seed Grant (NIMH) [P50-MH115874]
- BBRF
- McLean Hospital
- Harvard Catalyst | The Harvard Clinical and Translational Science Center [NCATS KL2TR002542, UL1TR002541]
- [R01MH117292]
- [P50MH115874]
- [R01MH106595]
Many individuals encounter traumatic stress at some point in their lives, increasing the risk of developing stress-related disorders such as PTSD, MDD, and ANX, which are influenced by genetics. Genome-wide association studies have shown a genetic overlap between PTSD, depression, and anxiety disorders, with efforts also made to understand these complex disorders through gene-environment studies.
Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these disorders is also influenced by genetics and have heritability estimates ranging between similar to 30 and 70%. In this review, we provide an overview of the findings of genome-wide association studies for PTSD, depression and ANX, and we observe a clear genetic overlap between these three diagnostic categories. We go on to highlight the results from transcriptomic and epigenomic studies, and, given the multifactorial nature of stress-related disorders, we provide an overview of the gene-environment studies that have been conducted to date. Finally, we discuss systems biology approaches that are now seeing wider utility in determining a more holistic view of these complex disorders.
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