期刊
BIOACTIVE MATERIALS
卷 6, 期 10, 页码 3383-3395出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.02.030
关键词
Composite; Collagen; Hydroxyapatite; Magnesium; Scaffold; Hard tissue regeneration; Scaffold degradation
资金
- Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI within PNCDI III [COFUND-M-ERA. NET II-BiogenInk/70/2017]
Novel composite scaffolds composed of collagen-hydroxyapatite and collagen-hydroxyapatite-magnesium were developed, showing promising potential for bone tissue engineering applications. The nanostructural properties and degradation behavior of the scaffolds were thoroughly investigated through advanced microscopy techniques.
bone and to be subsequently resorbed and replaced by endogenous tissues. Taking inspiration from basic composition of the mammalian bones, composed of collagen, apatite and a number of substitution ions, among them magnesium (Mg2+), in this work, novel composite scaffolds composed of collagen(10%)-hydroxyapatite (HAp)(90%) and collagen(10%)-HAp(80%)-Mg(10%) were developed. The lyophilization was used for composites preparation. An insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive X-Ray. The HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen fibrils. The samples were tested for degradation in Simulated Body Fluid (SBF) solution by soaking for up to 28 days. The release of Mg from collagen (10%)-HAp(80%)-Mg(10%) composite during the period of up to 21 days was attested, this composite being characterized by a decreased degradation rate with respect to the composite without Mg. The developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.
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