期刊
BIOACTIVE MATERIALS
卷 8, 期 -, 页码 124-139出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.06.007
关键词
Tendon; Collagen fibrillogenesis; Extracellular matrix; FIB-SEM; Biomimetic
资金
- National Key Research and Development Program of China [2018YFC1105100]
- NSFC [81772418, 81972099, 81871764, 82072463]
- Zhejiang Provincial Natural Science Foundation of China [LR20H060001]
- Fundamental Research Funds for the Central Universities
This review summarizes recent research on the structure and function of the extracellular matrix (ECM) components of tendons and highlights the application of multiple detection methodologies concerning the structure of ECMs. The focus is on macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. The review also emphasizes future ECM detection methods and the potential for fabricating biomimetic tendons.
Abnormal tendons are rarely ever repaired to the natural structure and morphology of normal tendons. To better guide the repair and regeneration of injured tendons through a tissue engineering method, it is necessary to have insights into the internal morphology, organization, and composition of natural tendons. This review summarized recent researches on the structure and function of the extracellular matrix (ECM) components of tendons and highlight the application of multiple detection methodologies concerning the structure of ECMs. In addition, we look forward to the future of multi-dimensional biomaterial design methods and the potential of structural repair for tendon ECM components. In addition, focus is placed on the macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. Finally, emphasis is given to future extracellular matrix detection methods, as well as to how future efforts could concentrate on fabricating the biomimetic tendons.
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