期刊
BIOACTIVE MATERIALS
卷 14, 期 -, 页码 234-249出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.11.015
关键词
Regenerative endodontics; Pulp regeneration; Tissue engineering; Stem cells; Scaffolds
资金
- NIH [R15 EY029504 01A1S1, R15 EY029504, R01DE025885]
- NSF [IIP 1903617]
- NJIT Undergraduate Research and Innovation (URI) Program
Pulp capping and dental pulp regeneration are evolving techniques to regenerate pulp tissue and maintain tooth vitality, with various methods and materials being used in regenerative endodontics.
The carious process leads to inflammation of pulp tissue. Current care options include root canal treatment or apexification. These procedures, however, result in the loss of tooth vitality, sensitivity, and healing. Pulp capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue, avoiding necrosis and loss of vitality. Many studies have successfully employed stem/progenitor cell populations, revascularization approaches, scaffolds or material-based strategies for pulp regeneration. Here we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative endodontics. We also summarize recent findings on efficacious peptide-based materials which target the dental niche.
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