期刊
BIOACTIVE MATERIALS
卷 6, 期 11, 页码 3839-3850出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.03.039
关键词
Mn-containing bioceramics; Antioxidant biomaterials; Osteoclastogenesis; ROS; Osteoporotic bone regeneration
资金
- Key Program of National Natural Science Foundation of China [81930067]
- Youth Program of National Natural Science Foundation of China [82002316]
- Youth Cultivation Project of Army Medical University [2020XQN08]
- General Program of Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0176]
This study demonstrated that Mn-containing bioceramics can scavenge ROS, inhibit osteoclastogenesis, promote osteoblast differentiation, and accelerate bone regeneration under osteoporotic conditions. The Mn-TCP bioceramics have the potential to be an ideal biomaterial for treating osteoporotic bone defects.
Osteoporosis is caused by an osteoclast activation mechanism. People suffering from osteoporosis are prone to bone defects. Increasing evidence indicates that scavenging reactive oxygen species (ROS) can inhibit receptor activator of nuclear factor.B ligand (RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis. It is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone defects. Previous studies have shown that manganese (Mn) can improve bone regeneration, and Mn supplementation may treat osteoporosis. However, the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain unclear. In present research, a model bioceramic, Mn-contained beta-tricalcium phosphate (Mn-TCP) was prepared by introducing Mn into beta-TCP. The introduction of Mn into beta-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals, demonstrating that Mn-TCP bioceramics might have antioxidant properties. The in vitro and in vivo findings revealed that Mn2+ ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts, promote the differentiation of osteoblasts, and accelerate bone regeneration under osteoporotic conditions in vivo. Mechanistically, Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 activation. These results suggest that Mn-containing bioceramics with osteoconductivity, ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect.
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