4.8 Article

Sudoku of porous, injectable calcium phosphate cements - Path to osteoinductivity

期刊

BIOACTIVE MATERIALS
卷 17, 期 -, 页码 109-124

出版社

KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.01.001

关键词

Calcium phosphate cements; Bone cements; Bone regeneration; Osteoinductivity

资金

  1. Riga TechnicalUniversity's Doctoral Grant programme
  2. European Union [857287]

向作者/读者索取更多资源

With the increase in global population, the demand for bone substitutes is growing. Calcium phosphate cements (CPCs) have the potential for various applications in bone regeneration due to their ability to self-set and resorb. However, finding an osteoinductive material that is suitable for injection remains a challenge.
With the increase of global population, people's life expectancy is growing as well. Humans tend to live more active lifestyles and, therefore, trauma generated large defects become more common. Instances of tumour resection or pathological conditions and complex orthopaedic issues occur more frequently increasing necessity for bone substitutes. Composition of calcium phosphate cements (CPCs) is comparable to the chemical structure of bone minerals. Their ability to self-set and resorb in vivo secures a variety of potential applications in bone regeneration. Despite the years-long research and several products already reaching the market, finding the right properties for calcium phosphate cement to be osteoinductive and both injectable and suitable for clinical use is still a sudoku. This article is focused on injectable, porous CPCs, reviewing the latest developments on the path toward finding osteoinductive material, which is suitable for injection.

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