期刊
BIOACTIVE MATERIALS
卷 16, 期 -, 页码 372-387出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.01.002
关键词
Torpedoes-inspired; Microcluster colloidosomes; Magnetic guidance; Disintegration; Hemostasis
资金
- China Agriculture Research System [CARS-18-ZJ0102]
- National Natural Science Foundation of China [52103096, 51803170, 51803171, 81703424]
- Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0383]
- Fundamental Research Funds for the Central Uni-versities [2020CDJQY-A041]
Inspired by torpedoes, researchers developed a novel strategy to deliver hemostats into deep wounds using microcluster colloidosomes equipped with magnetic-mediated navigation and blast systems. The study demonstrated rapid and effective hemostasis in a vase-type hemorrhage model, and also showed excellent biodegradability in vivo.
Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature, thereby causing massive blood loss and significantly increased mortality. Inspired by the attack action of torpedoes, we synthesized microcluster (MC) colloidosomes equipped with magnetic-mediated navigation and blast systems to deliver hemostats into the cavity of vase-type wounds. CaCO3/Fe2O3 (CF) microparticles functionalized with Arg-Gly-Asp (RGD) modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots (CDs) to form MC colloidosomes, which were loaded with thrombin and protonated tranexamic acid (TXA-NH3+). The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH3+. The CO2 bubbles generated during disassembly produced a blast that propelled thrombin into the wound cavity. Severe bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within similar to 60 s. Furthermore, in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC colloidosomes. This study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis, creating a new paradigm for combating trauma treatment.
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