期刊
BIOACTIVE MATERIALS
卷 6, 期 10, 页码 3461-3472出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.03.009
关键词
Polylactide; Nanofibrous membrane; Redox sensitivity; ROS-Balance capacity; Skin regeneration
资金
- National Key R&D Program of China [2018YFE0201500, 2017YFB0309300]
- National Natural Science Foundation of China [81772317, 51973060, 82072051, 81771964, 51621002]
- Natural Science Foundation of Heilongjiang Province [LH2020H076]
- Shanghai International Cooperation Program [15520721200]
- Joint research project of important diseases in Xuhui District [XHLHGG201802]
- Fundamental Research Funds for the Shanghai Municipal Commission of Health and Family Planning [201740034]
- [WD1714002]
The study successfully developed bioabsorbable materials with ROS regulation capacity, showing great potential in wound healing. The materials can improve cell adhesion and proliferation, promote the wound healing process, and achieve higher healing efficacy by adjusting the ROS levels in the wound area.
Facing the high incidence of skin diseases, it is urgent to develop functional materials with high bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in the wound healing process mainly via adjustment of immune response and neovasculation. In this study, we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy. Firstly, redox-sensitive poly(N-isopropylacrylamide-acrylic acid) (PNA) nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker. The resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid) (PLLA) via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity. In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane. In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process, where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据