☆ 4.8 Article

Monitoring Retinoblastoma by Machine Learning of Aqueous Humor Metabolic Fingerprinting

SMALL METHODS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population-Based Study of 1,355 Adults

Louise J. M. Alferink et al.

Summary: This study found a decrease in gut microbial diversity in patients with steatosis, and identified associations of Coprococcus and Ruminococcus Gnavus with steatosis. The metabolic profile in patients with steatosis showed opposite correlations with alpha diversity, indicating a complex relationship between gut microbiome, metabolism, and liver health.

HEPATOLOGY (2021)

添加到收藏夹

Article Ophthalmology

How Telemedicine and Centralized Care Changed the Natural History of Retinoblastoma in a Developing Country Analysis of 478 Patients

Yacoub A. Yousef et al.

Summary: The implementation of a telemedicine-based twinning program at King Hussein Cancer Centre significantly reduced the mortality rate and increased the overall eye salvage rate for retinoblastoma patients. The survival and eye-salvage rates remained comparable at both early and later stages of the twinning program implementation.

OPHTHALMOLOGY (2021)

添加到收藏夹

Article Ophthalmology

Disruption of blood-aqueous barrier in dry eye disease

Hossein Aghaei et al.

Summary: The study found a significant increase in aqueous humor flare in patients with dry eye disease, indicating deeper tissue involvement beyond the ocular surface. There was a significant correlation between flare intensity and ocular surface staining in the Sjogren's syndrome dry eye group.

OCULAR SURFACE (2021)

添加到收藏夹

Article Ophthalmology

Global Retinoblastoma Treatment Outcomes Association with National Income Level

Ankit Singh Tomar et al.

Summary: The study revealed that patients with retinoblastoma in lower and middle-income countries had higher rates of metastasis-related mortality and local treatment failure compared to patients in higher-income countries, indicating poorer treatment outcomes in lower income settings.

OPHTHALMOLOGY (2021)

添加到收藏夹

Article Biophysics

MOF-enzyme hybrid nanosystem decorated 3D hollow fiber membranes for in-situ blood separation and biosensing array

Huimin Wu et al.

Summary: The study successfully addressed the limitation of 1D or 2D structures by assembling modified MOF-enzyme hybrid nanosystem into 3D porous conductive supports via a physical embedding method, showcasing high stability and catalytic performance. Furthermore, the multifunctional device integrated with conductive hollow fiber membranes demonstrated fast capillary fluid flow, trace sampling, high selectivity, and accuracy in sensing applications.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoparticle-Assisted Cation Adduction and Fragmentation of Small Metabolites

Shiyu Sun et al.

Summary: This study investigated cation adduction and fragmentation of small metabolites using a combination of theoretical and experimental approaches, establishing rules and successfully controlling fragmentation to enhance metabolite identification and profiling. This work provides new insights for advanced analysis of small metabolites in mass spectrometry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Oncology

Proteogenomic and metabolomic characterization of human glioblastoma

Liang-Bo Wang et al.

Summary: Understanding the molecular pathogenesis of glioblastoma is crucial for improving diagnosis and treatment. Integrated analysis of genomic, proteomic, and metabolomic data on treatment-naive glioblastomas has identified key phosphorylation events and potential targets for specific tumor alterations. Immune subtypes with distinct immune cell types were discovered, and specific histone acetylation patterns were correlated with these subtypes, providing insights for stratification of patients for more effective treatment.

CANCER CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity

Maik Pietzner et al.

Summary: The study identified shared pathways contributing to the multimorbidity of noncommunicable diseases using untargeted metabolomics profiling and integrated various risk factors and characteristics to identify actionable shared pathways.

NATURE MEDICINE (2021)

添加到收藏夹

Review Oncology

Metabolic Codependencies in the Tumor Microenvironment

Prasenjit Dey et al.

Summary: Cancer cell metabolic reprogramming is driven by signals from both intrinsic and extrinsic factors. Intrinsic signaling maintains the baseline metabolic state, while extrinsic signals fine-tune metabolic processes based on metabolite availability and cellular requirements. Therefore, successful targeting of metabolic pathways will require a nuanced approach based on cancer genotype, tumor microenvironment composition, and tissue location.

CANCER DISCOVERY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Detection of Single Cancer Cells in Blood with Artificially Intelligent Nanoarray

Reef Einoch-Amor et al.

Summary: The study introduces an artificially intelligent nanoarray using chemisensitive nanostructured films for detecting single cancer cells in blood samples, showing high accuracy, sensitivity, and specificity. The technology is not affected by the medium or environment, and could potentially be used for early cancer detection and continuous monitoring.

ACS NANO (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Plasmonic Alloys Reveal a Distinct Metabolic Phenotype of Early Gastric Cancer

Haiyang Su et al.

Summary: The article introduces a mesoporous PdPtAu alloy designed to characterize metabolic profiles in human blood, enabling precise diagnosis of early gastric cancer by optimizing elemental composition and surface structure.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Analytical

On-Demand Mass Spectrometry Analysis by Miniature Mass Spectrometer

Junhan Wu et al.

Summary: A novel on-demand MS analysis method was developed based on discontinuous ion injection-induced ESI on a miniature MS system, enabling highly efficient ionization under low voltages. This method was found to be softer for ionization of proteins and allowed single-cell analysis with reduced sample consumption.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Oncology

Metabolomics in cancer research and emerging applications in clinical oncology

Daniel R. Schmidt et al.

Summary: Cancer has complex effects on cellular and systemic metabolism, with metabolomics playing a crucial role in providing insights for cancer diagnosis, monitoring, and therapy. Advances in technology have expanded the applications of metabolomics in clinical research, with the potential to further enhance cancer patient management in the future.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Oncology

Liquid Biopsy: From Discovery to Clinical Application

Catherine Alix-Panabieres et al.

Summary: CTC and ctDNA have been recognized as promising biomarkers with various clinical applications, including early cancer detection and therapeutic monitoring. However, challenges such as standardization and validation of clinical effectiveness need to be addressed in this dynamic field of translational cancer research.

CANCER DISCOVERY (2021)

添加到收藏夹

Review Oncology

The Impact of Cell-Free DNA Analysis on the Management of Retinoblastoma

Amy Gerrish et al.

Summary: Retinoblastoma is a childhood eye cancer primarily caused by mutations in the RB1 gene. Cell-free DNA analysis has the potential to impact diagnosis and treatment, including tumor diagnosis, prognosis, and prenatal diagnosis in pregnant women.

CANCERS (2021)

添加到收藏夹

Article Oncology

Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid Biopsy

Liya Xu et al.

Summary: This study demonstrates the clinical utility of molecular profiling of aqueous humor (AH) in retinoblastoma patients, providing valuable information for diagnosis, prognosis, and treatment response monitoring. Liquid biopsy using AH allows for the detection of tumor-derived biomarkers with a potential for personalized treatment.

CANCERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Zhiqiang Pang et al.

Summary: MetaboAnalyst version 5.0 has been introduced to facilitate comprehensive metabolomics data analysis and interpretation, with the aim of narrowing the gap from raw data to functional insights. Three new modules have been developed to assist in this goal, along with various other new functions and improvements in interface, graphics, and codebase. Users can now easily switch between compatible modules for a streamlined data analysis experience.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultra-Fast Label-Free Serum Metabolic Diagnosis of Coronary Heart Disease via a Deep Stabilizer

Mengji Zhang et al.

Summary: This study introduces a deep stabilizer for ultra-fast, label-free MS detection in serum metabolic diagnosis of coronary heart disease (CHD). By utilizing nanoparticle-assisted laser desorption/ionization-MS, direct metabolic analysis of trace unprocessed serum can be achieved in seconds, leading to advanced accuracy in CHD diagnosis. The development of this stabilized platform advances the design of metabolic analysis tools for disease detection in clinics.

ADVANCED SCIENCE (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Advances in surface-enhanced Raman scattering bioprobes for cancer imaging

Jie Lin et al.

Summary: SERS technology, with its high sensitivity and nondestructive properties, has been widely utilized in bioanalysis, particularly in the field of cancer diagnosis and therapy. SERS bioimaging has successfully achieved cancer screening, diagnosis, and componential analysis, offering visual morphology and biochemical information simultaneously. High-performance Raman image bioprobes enable precise tumor tissue excision, real-time monitoring of cellular uptake process, and noninvasive cell tracking and labeling.

VIEW (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Biointerfaced sensors for biodiagnostics

Orr Zohar et al.

Summary: Biointerfaced sensors are a new paradigm in medical applications that require contact with biological components. This article reviews the concept, design, and characteristics of these sensors for successful biodiagnostics and monitoring. It discusses considerations for artificial interfaces with different biological environments, strategies for sensor and material design, and the importance of maintaining an undisturbed interface with the surrounding biological environment. The review also highlights successful demonstrations in body monitoring and biodiagnostics, with recommendations for future research.

VIEW (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

On-demand field shaping for enhanced magnetic resonance imaging using an ultrathin reconfigurable metasurface

Hanwei Wang et al.

Summary: The signal-to-noise ratio (SNR) is crucial in evaluating the quality of magnetic resonance imaging (MRI). Our innovative approach focuses on improving the coupling between the imaging subject and the RF coil during signal reception to enhance SNR. Our design features a reconfigurable ultrathin metasurface that can selectively boost SNR in desired imaging regions while maintaining excitation uniformity.

VIEW (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

Xiao Jin et al.

Summary: MRI is a noninvasive technique with high spatial resolution, but traditional contrast agents always have poor target-to-background signal ratio. Activatable CAs with design strategies such as ion conversion, self-assembly, and disassembly significantly improve the TBR and show advantages in biomedical applications compared to conventional CAs.

VIEW (2021)

添加到收藏夹

Review Chemistry, Analytical

Combined Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry Approaches for Metabolomics

Marine P. M. Letertre et al.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Review Spectroscopy

The integration of LC-MS and NMR for the analysis of low molecular weight trace analytes in complex matrices

Rose M. Gathungu et al.

MASS SPECTROMETRY REVIEWS (2020)

添加到收藏夹

Editorial Material Ophthalmology

Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma

Jesse L. Berry et al.

OPHTHALMOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Urine Metabolic Fingerprints Encode Subtypes of Kidney Diseases

Jing Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metabolic Fingerprinting on Synthetic Alloys for Medulloblastoma Diagnosis and Radiotherapy Evaluation

Jing Cao et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Metabolic reprogramming and cancer progression

Brandon Faubert et al.

SCIENCE (2020)

添加到收藏夹

Article Oncology

Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival

Liya Xu et al.

MOLECULAR CANCER RESEARCH (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

Gregory D. Poore et al.

NATURE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Vanadium Core-Shell Nanorods Inspect Metabolic Changes of Diabetic Retinopathy

Vadanasundari Vedarethinam et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women

Liang Liang et al.

CELL (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Detection of SARS-CoV-2 in nasal swabs using MALDI-MS

Fabiane M. Nachtigall et al.

NATURE BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

Farshad Nassiri et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma

Lin Huang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Rapid Computer-Aided Diagnosis of Stroke by Serum Metabolic Fingerprint Based Multi-Modal Recognition

Wei Xu et al.

ADVANCED SCIENCE (2020)

添加到收藏夹

Article Cell Biology

Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

Michela Perego et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Oncology

MR Imaging Features to Differentiate Retinoblastoma from Coats' Disease and Persistent Fetal Vasculature

Robin W. Jansen et al.

CANCERS (2020)

添加到收藏夹

Review Oncology

Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives

Arnaud Martel et al.

CANCERS (2020)

添加到收藏夹

Article Cell Biology

Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01

Guillem Pascual-Pasto et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Review Ophthalmology

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. Alive, with good vision and no comorbidity

Francis L. Munier et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2019)

添加到收藏夹

Review Chemistry, Analytical

Direct sampling mass spectrometry for clinical analysis

Fan Pu et al.

ANALYST (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

HMDB 4.0: the human metabolome database for 2018

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2018)

添加到收藏夹

Article Cell Biology

Aspartate is an endogenous metabolic limitation for tumour growth

Lucas B. Sullivan et al.

NATURE CELL BIOLOGY (2018)

添加到收藏夹

Article Oncology

Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma

Jesse L. Berry et al.

MOLECULAR CANCER RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Plasmonic silver nanoshells for drug and metabolite detection

Lin Huang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Chemistry, Analytical

LC-MS-Based Metabolic Fingerprinting of Aqueous Humor

Karolina Pietrowska et al.

JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2017)

添加到收藏夹

Article Ophthalmology

Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma

Jesse L. Berry et al.

JAMA OPHTHALMOLOGY (2017)

添加到收藏夹

Article Cell Biology

Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth

Siyuan Xia et al.

CELL METABOLISM (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis

A. S. Nagaraja et al.

ONCOGENE (2016)

添加到收藏夹

Article Ophthalmology

BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions

Ann-Cathrine Larsen et al.

ACTA OPHTHALMOLOGICA (2016)

添加到收藏夹

Editorial Material Ophthalmology

Clinical significance of high levels of survivin and transforming growth factor beta-1 proteins in aqueous humor and serum of retinoblastoma patients

Hanan Hussein Shehata et al.

JOURNAL OF AAPOS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Lucas B. Sullivan et al.

CELL (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

Hee-Bum Kang et al.

MOLECULAR CELL (2015)

添加到收藏夹

Article Medicine, General & Internal

Retinoblastoma

Helen Dimaras et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

添加到收藏夹

Article Ophthalmology

Retcam fluorescein angiography findings in eyes with advanced retinoblastoma

Jonathan W. Kim et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2014)

添加到收藏夹

Review Ophthalmology

Diagnostic Performance of Magnetic Resonance Imaging and Computed Tomography for Advanced Retinoblastoma: A Systematic Review and Meta-analysis

Marcus C. de Jong et al.

OPHTHALMOLOGY (2014)

添加到收藏夹

Article Statistics & Probability

Regularization and variable selection via the elastic net

H Zou et al.

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.