期刊
CANCER COMMUNICATIONS
卷 42, 期 2, 页码 88-116出版社
WILEY
DOI: 10.1002/cac2.12250
关键词
cancer; ferroptosis; immunotherapy
类别
资金
- Ministry of Science and Technology of China [2016YFA0502500]
- Chinese National Natural Science Funds [U20A201376, 31925013, 82041009, 31871405, 31701232]
- Jiangsu National Science Foundation [BK20180043]
- Science and Technology Plan Project of Suzhou [SYS2019020]
Ferroptosis, a newly identified type of cell death dependent on lipid peroxidation, plays a vital role in cancer treatment as a potential strategy to overcome drug resistance in traditional therapies.
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry. The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure. The effective rate of tumor immunotherapy as a new treatment method is less than 30%. Ferroptosis can be seen in radiotherapy, chemotherapy, and tumor immunotherapy; therefore, ferroptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments. In this review, the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized. Collectively, these findings suggest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy, chemotherapy and radiotherapy, thus, indicating the remarkable potential of ferroptosis in cancer treatment.
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