Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics

Article Hematology

Complement dysregulation is associated with severe COVID-19 illness

Jia Yu et al.

Summary: The serum of COVID-19 patients can induce complement-mediated cell death and is associated with dysregulation of APC, which may contribute to the pathogenesis and severity of the disease.

HAEMATOLOGICA (2022)

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Article Emergency Medicine

Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis

Anwar Santoso et al.

Summary: This study found that cardiac injury in patients with COVID-19 pneumonia is associated with higher mortality, need for ICU care, and severity of the disease. However, cardiac injury does not significantly increase the risk of ARDS.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Review Endocrinology & Metabolism

Diabetes increases the mortality of patients with COVID-19: a meta-analysis

Zeng-hong Wu et al.

Summary: This meta-analysis revealed a significant correlation between diabetes and mortality of COVID-19 patients. The results suggest that blood glucose disturbance in COVID-19 patients may contribute to worsened outcomes.

ACTA DIABETOLOGICA (2021)

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Review Clinical Neurology

Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis

Maria Epifania V. Collantes et al.

Summary: The review on neurological manifestations and complications in COVID-19 revealed that symptoms like headache, dizziness, and myalgia were common, while vascular disorders were the most frequent neurological complication. Most patients with neurological complications survived, highlighting the multi-organ nature of the disease previously thought to be respiratory.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2021)

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Article Clinical Neurology

Increased risk of acute stroke among patients with severe COVID-19: a multicenter study and meta-analysis

T. Siepmann et al.

Summary: The risk of acute stroke in COVID-19 patients is associated with disease severity, with severe cases having a higher risk compared to non-severe cases. This was concluded from a multicenter study and systematic review of observational studies, indicating an increased likelihood of stroke occurrence in more severe cases.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

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Article Medicine, General & Internal

Assessment and characterisation of post-COVID-19 manifestations

Marwa Kamal et al.

Summary: The study found that the majority of COVID-19 survivors experience post-viral symptoms, with fatigue being the most common, and some experiencing severe complications such as stroke and myocarditis. The presence of comorbidities prior to COVID-19 infection is related to the severity of post-COVID-19 manifestations.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Review Geriatrics & Gerontology

Venous thromboembolic events in patients with COVID-19: a systematic review and meta-analysis

Ting Wu et al.

Summary: Venous thromboembolism (VTE) is common in severe COVID-19 patients, with higher incidence in older individuals and male patients. Elevated levels of WBC, D-dimer, APTT, fibrinogen, and CRP were commonly observed in COVID-19 patients with VTE, while lower level of lymphocyte was associated with high risk of developing VTE. Severe condition was more likely to occur in COVID-19 patients who developed VTE, suggesting that thromboembolic events are associated with adverse outcomes in COVID-19 patients.

AGE AND AGEING (2021)

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Article Surgery

Acute Limb Ischemia in a Peruvian Cohort Infected by COVID-19

Juan Bautista Sanchez et al.

Summary: The study described clinical and surgical characteristics of a group of patients infected with COVID-19 who presented ALI, finding that the mean age of these patients was 60 years with main comorbidities being arterial hypertension, obesity, and type 2 diabetes. Despite a high rate of thrombectomy, 30% of patients underwent amputations, with a mortality rate of 23.3%.

ANNALS OF VASCULAR SURGERY (2021)

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Review Cardiac & Cardiovascular Systems

Prevalence and impact of cardiac injury on COVID-19: A systematic review and meta-analysis

Linghua Fu et al.

Summary: The prevalence and impact of cardiac injury in hospitalized patients with COVID-19 remains controversial. This study aimed to investigate the prevalence of cardiac injury and its impact on outcomes. The results showed that cardiac injury is common in advanced age and severe COVID-19 patients, and is associated with an increased risk of all-cause mortality.

CLINICAL CARDIOLOGY (2021)

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Review Virology

Obesity aggravates COVID-19: An updated systematic review and meta-analysis

Jun Yang et al.

Summary: This review evaluated the impact of obesity on COVID-19 and found that obese individuals were more likely to test positive for the virus and had higher risks of hospitalization, ICU admission, invasive mechanical ventilation, and in-hospital mortality. A higher degree of obesity also indicated higher risks, and regional differences may contribute to study heterogeneity. Further research is needed to strengthen basic and clinical therapeutic approaches.

JOURNAL OF MEDICAL VIROLOGY (2021)

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News Item Critical Care Medicine

NICE guideline on long COVID

Priya Venkatesan

LANCET RESPIRATORY MEDICINE (2021)

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Review Surgery

Systematic review and meta-analysis of the prevalence of venous thromboembolic events in novel coronavirus disease-2019 patients

Rui Zhang et al.

Summary: Venous thromboembolism is common in patients hospitalized with COVID-19, especially among ICU patients. Screening tests for PE and DVT can significantly improve detection rates in both ICU and non-ICU patients with COVID-19.

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS (2021)

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Review Cardiac & Cardiovascular Systems

Prevalence of Venous Thromboembolism in Critically Ill COVID-19 Patients: Systematic Review and Meta-Analysis

Mouhand F. H. Mohamed et al.

Summary: Recent studies have shown a high prevalence of VTE in critically ill COVID-19 patients, with nearly 50% of patients detected with VTE through systematic screening. Initial analysis suggests that prophylactic anticoagulation may significantly increase the risk of VTE compared to therapeutic anticoagulation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Editorial Material Pediatrics

COVID-19 related increase in childhood tics and tic-like attacks

Isobel Heyman et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

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Review Medicine, General & Internal

Cardiac Complications in COVID-19: A Systematic Review and Meta-analysis

Mehrdad Sahranavard et al.

Summary: This study systematically reviewed cardiac complications in COVID-19 patients, finding pooled incidence rates of 10.11% for arrhythmia, 17.85% for myocardial injury, and 22.34% for heart failure. The pooled level of unadjusted cTnI was significantly higher in expired cases compared with surviving cases.

ARCHIVES OF IRANIAN MEDICINE (2021)

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Review Critical Care Medicine

Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis

David Jimenez et al.

Summary: The pooled incidence of VTE and bleeding among hospitalized patients with COVID-19 was 17.0% and 7.8% respectively. Factors such as routine screening, critical illness, inclusion of distal DVT and subsegmental PE, and prospective studies were associated with higher rates of VTE. The incidence of bleeding events was sensitive to escalated doses of anticoagulants and the nature of data collection.

CHEST (2021)

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Article Immunology

Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19

Luca Valenti et al.

Summary: This study found an association between genetic variation at chromosome 3p21.31 and ABO blood group with complement activation in COVID-19 patients, providing insights into the pathogenesis of severe COVID-19.

JOURNAL OF AUTOIMMUNITY (2021)

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Review Neurosciences

Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors

Isabel Siow et al.

Summary: Stroke as a complication of COVID-19 is not common but can lead to significant morbidity and mortality. The average age of patients with COVID-19 who suffered from stroke was 65.5 years, with an incidence of approximately 1.74% and a mortality rate of around 31.76%. These patients also displayed deranged clinical parameters such as coagulation profiles, liver function tests, and full blood counts.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Review Neurosciences

The Incidence and Mortality Ratio of Ischemic Cerebrovascular Accidents in COVID-19 Cases: A Systematic Review and Meta-Analysis

Sina Parsay et al.

Summary: The analysis revealed a pooled incidence of 1.7% for ischemic CVA in the setting of COVID-19 infection, with a mortality rate of 29.2% among COVID-19 patients with ischemic CVA.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Article Multidisciplinary Sciences

Fatigue following COVID-19 infection is not associated with autonomic dysfunction

Liam Townsend et al.

Summary: The study found that fatigue, symptoms of autonomic dysfunction, and anxiety were common in post-COVID-19 infection patients, but there were no pathological findings on autonomic testing.

PLOS ONE (2021)

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Article Peripheral Vascular Disease

Acute Limb Ischemia in Hospitalized COVID-19 Patients

Ahmet Can Topcu et al.

ANNALS OF VASCULAR SURGERY (2021)

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Article Hematology

Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C

Hilary Whitworth et al.

Summary: This study found that age >= 12 years, cancer, presence of a central venous catheter, and MIS-C were significantly associated with thrombosis in children hospitalized with COVID-19 or MIS-C. It is notable that the majority of thrombotic events occurred in patients aged 12 years and older, and nearly one-third of patients experienced thrombosis despite receiving thromboprophylaxis.

BLOOD (2021)

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Review Clinical Neurology

Neurological manifestations and complications of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis

Ahmed Yassin et al.

Summary: Neurological involvement is common in COVID-19 patients, and early recognition and vigilance of such involvement might impact their overall outcomes.

BMC NEUROLOGY (2021)

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Article Medical Laboratory Technology

High-Sensitivity Cardiac Troponin T for the Detection of Myocardial Injury and Risk Stratification in COVID-19

Laura De Michieli et al.

Summary: Myocardial injury is common and predictive in COVID-19 patients, with most hs-cTnT increases related to myocardial injury and having significant prognostic implications. A single hs-cTnT <6 ng/L at presentation may help identify patients with a favorable prognosis.

CLINICAL CHEMISTRY (2021)

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Article Immunology

Genetic justification of severe COVID-19 using a rigorous algorithm

Eleni Gavriilaki et al.

Summary: This study identified genetic susceptibility in severe COVID-19 patients, particularly in relation to ADAMTS13 and other complement-related variants, which were associated with ICU hospitalization. The findings suggest a specific patient population that may benefit from early initiation of targeted treatment.

CLINICAL IMMUNOLOGY (2021)

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Review Peripheral Vascular Disease

Venous thromboembolism in COVID-19: A systematic review and meta-analysis

Anastasios Kollias et al.

Summary: Severe COVID-19 is associated with an increased risk of VTE, with higher prevalence in patients with higher D-dimer levels and a higher percentage of ICU patients. The pooled odds ratio for death in COVID-19 patients with VTE versus those without VTE was 2.1, indicating a higher mortality risk. Preventive anticoagulation therapy should be investigated further for individualized VTE risk assessment in COVID-19 patients.

VASCULAR MEDICINE (2021)

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Editorial Material Medical Laboratory Technology

Mechanisms of Myocardial Injury in COVID-19

Anda Bularga et al.

CLINICAL CHEMISTRY (2021)

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Editorial Material Medicine, General & Internal

Confronting Our Next National Health Disaster - Long-Haul Covid

Steven Phillips et al.

Summary: Long Covid could potentially become the next national health disaster, and it is important to address and find solutions for it.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Pharmacology & Pharmacy

Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis

Vicky Mai et al.

Summary: A systematic review and meta-analysis compared the rate of venous thromboembolism (VTE) between COVID-19 and non-COVID-19 cohorts, finding no significant difference overall, but indicating an increased risk of VTE in COVID-19 patients hospitalized in the intensive care unit (ICU).

VASCULAR PHARMACOLOGY (2021)

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Review Medicine, General & Internal

Prevalence and Impact of Atrial Fibrillation in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Giulio Francesco Romiti et al.

Summary: In COVID-19 patients, the prevalence of AF is as high as 8%, and those with AF tend to be older, have hypertension, and be more likely to have critical conditions. Patients with AF in COVID-19 have a significantly higher risk of all-cause mortality.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, Research & Experimental

COVID-19-Associated Cardiovascular Complications

Clement C. E. Lee et al.

Summary: COVID-19 has been reported to cause cardiovascular complications such as myocardial injury, thromboembolic events, arrhythmia, and heart failure through multiple mechanisms, potentially related to direct viral invasion of cardiomyocytes or inflammation.

DISEASES (2021)

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Article Andrology

COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical , and Ultrastructural Study of the Human Penis

Eliyahu Kresch et al.

Summary: The study identified the presence of COVID-19 virus in penile tissue long after initial infection, as well as suggested that widespread endothelial cell dysfunction from COVID-19 infection may contribute to erectile dysfunction. This study lays the groundwork for further research into the molecular mechanisms by which COVID-19 infection leads to ED.

WORLD JOURNAL OF MENS HEALTH (2021)

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Review Clinical Neurology

Neurological Symptoms, Comorbidities, and Complications of COVID-19: A Literature Review and Meta-Analysis of Observational Studies

Kimia Vakili et al.

Summary: The most prevalent neurological symptoms of COVID-19 include fatigue, gustatory dysfunction, anorexia, olfactory dysfunction, headache, dizziness, and nausea. Cerebrovascular disease is the most common neurological comorbidity in COVID-19.

EUROPEAN NEUROLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Cardiovascular complications of SARS-CoV-2 infection (COVID-19): a systematic review and meta-analysis

Yu-Hao Zhao et al.

Summary: The most common cardiovascular complications in COVID-19 patients were myocardial injury and arrhythmia, with higher incidence in non-survivors. Heart failure and cardiac injury were more common in patients who died, regardless of a history of cardiovascular disease. Monitoring of cardiac reactions in COVID-19 patients is crucial for optimal care.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

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Review Hematology

Venous Thromboembolism, Corticosteroids and COVID-19: A Systematic Review and Meta-Analysis

Azza Sarfraz et al.

Summary: COVID-19 patients treated with corticosteroids are at higher risk of developing VTE, emphasizing the importance of individual risk assessment to reduce VTE incidence and improve clinical outcomes.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Article Medicine, General & Internal

Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study)

Terence Stephenson et al.

Summary: This study aims to describe the clinical phenotype of Long COVID in children and young people, produce an operational definition, and establish its prevalence in this population. A cohort study will be conducted, analyzing trajectories over time using data visualization techniques and cross-tabulation methods to aid in defining Long COVID.

BMJ OPEN (2021)

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Article Virology

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

Yushun Wan et al.

JOURNAL OF VIROLOGY (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Immunology

Is COVID-19 receiving ADE from other coronaviruses?

Jason A. Tetro

MICROBES AND INFECTION (2020)

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Editorial Material Biochemistry & Molecular Biology

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Article Immunology

COVID-19 presenting as stroke

Akshay Avula et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Letter Hematology

Severe COVID-19 infection and thrombotic microangiopathy: success does not come easily

Eleni Gavriilaki et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

Tomasz J. Guzik et al.

CARDIOVASCULAR RESEARCH (2020)

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Letter Cardiac & Cardiovascular Systems

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

Liang Chen et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Critical Care Medicine

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

Julie Helms et al.

INTENSIVE CARE MEDICINE (2020)

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Review Medicine, Research & Experimental

Complementopathies and precision medicine

Eleni Gavriilaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Editorial Material Virology

Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Alberto Paniz-Mondolfi et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Hematology

Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines

Zhenguo Zhai et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

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Review Peripheral Vascular Disease

Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression

Raymond Pranata et al.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2020)

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Article Hematology

Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19

Alex C. Spyropoulos et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Cardiac & Cardiovascular Systems

Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum

Geoffrey D. Barnes et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Surgery

Acute limb ischemia in patients with COVID-19 pneumonia

Raffaello Bellosta et al.

JOURNAL OF VASCULAR SURGERY (2020)

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Article Medicine, General & Internal

Hyperinflammatory shock in children during COVID-19 pandemic

Shelley Riphagen et al.

LANCET (2020)

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Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Article Medicine, General & Internal

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

Lucio Verdoni et al.

LANCET (2020)

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Article Clinical Neurology

Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy

Alberto Benussi et al.

NEUROLOGY (2020)

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Article Clinical Neurology

Neurologic manifestations in hospitalized patients with COVID-19 The ALBACOVID registry

Carlos Manuel Romero-Sanchez et al.

NEUROLOGY (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

SARS-CoV-2 Infection in Children

Xiaoxia Lu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Immunology

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

Sara Mastaglio et al.

CLINICAL IMMUNOLOGY (2020)

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Article Hematology

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

Hanny Al-Samkari et al.

BLOOD (2020)

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Article Immunology

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

Alessandro Rambaldi et al.

IMMUNOBIOLOGY (2020)

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Article Infectious Diseases

A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19

Ying-feng Lu et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

Elizabeth Whittaker et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Letter Medicine, General & Internal

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City

Eva W. Cheung et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Medicine, General & Internal

Venous Thromboembolism among Hospitalized Patients with COVID-19 Undergoing Thromboprophylaxis: A Systematic Review and Meta-Analysis

Gerald Chi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Virology

Coagulation disorders in coronavirus infected patients: COVID-19, SARS- CoV-1, MERS-CoV and lessons from the past

Dimitrios Giannis et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Incidence of Venous Thromboembolism in Hospitalized Coronavirus Disease 2019 Patients: A Systematic Review and Meta-Analysis

Chi Zhang et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

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Review Virology

Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: A meta-regression and decision tree analysis

Eman A. Toraih et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Venous thromboembolism in critically ill COVID-19 patients receiving prophylactic or therapeutic anticoagulation: a systematic review and meta-analysis

Syed Shahzad Hasan et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Hematology

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Jia Yu et al.

BLOOD (2020)

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Review Neurosciences

Neurological manifestations in COVID-19: a systematic review and meta-analysis

Tzy Harn Chua et al.

BRAIN INJURY (2020)

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Article Biochemistry & Molecular Biology

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

Vijendra Ramlall et al.

NATURE MEDICINE (2020)

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in US Children and Adolescents

Leora R. Feldstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in Children in New York State

Elizabeth M. Dufort et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Cardiac & Cardiovascular Systems

Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19

Matthias H. Busch et al.

CIRCULATION (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Severe COVID-19 Is a Microvascular Disease

Charles J. Lowenstein et al.

CIRCULATION (2020)

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Review Peripheral Vascular Disease

Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses

Eleni Gavriilaki et al.

CURRENT HYPERTENSION REPORTS (2020)

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Review Hematology

Venous thromboembolism in patients with COVID-19: Systematic review and meta-analysis

Angelo Porfidia et al.

THROMBOSIS RESEARCH (2020)

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Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Clinical Neurology

Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions

T. T. Favas et al.

NEUROLOGICAL SCIENCES (2020)

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Article Multidisciplinary Sciences

Impact of cardiovascular risk profile on COVID-19 outcome. A meta-analysis

Jolanda Sabatino et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

Jan C. Holter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Hematology

COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies

Alessandro Di Minno et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2020)

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Review Clinical Neurology

Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis

Kai Wei Lee et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Cell Biology

Incidence of cerebrovascular disease as a comorbidity in patients with COVID-19: A meta-analysis

Jun Zhang et al.

Aging-US (2020)

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Article Medicine, General & Internal

Facing up to long COVID

The Lancet

LANCET (2020)

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Review Medicine, General & Internal

Clinical symptoms, comorbidities and complications in severe and non-severe patients with COVID-19 A systematic review and meta-analysis without cases duplication

Zhufeng Wang et al.

MEDICINE (2020)

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Correction Hematology

Incidence of thromboembolism in patients with COVID-19: a systematic review and meta-analysis (vol 18, 34, 2020)

Kochawan Boonyawat et al.

THROMBOSIS JOURNAL (2020)

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Review Medicine, General & Internal

Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: A systematic review and meta-analysis

Mahmoud B. Malas et al.

ECLINICALMEDICINE (2020)

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Review Medicine, General & Internal

Acute Cardiac Injury in COVID-19: A Systematic Review and Meta-analysis

Mehrbod Vakhshoori et al.

ARCHIVES OF IRANIAN MEDICINE (2020)

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