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Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics

期刊

JOURNAL OF LABORATORY MEDICINE
卷 45, 期 6, 页码 293-302

出版社

WALTER DE GRUYTER GMBH
DOI: 10.1515/labmed-2021-0134

关键词

COVID-19; endothelial dysfunction; long COVID-19; pediatric; SARS-COV-2; thrombosis

资金

  1. AMERICAN SOCIETY OF HEMATOLOGY (ASH) Global Research Award

向作者/读者索取更多资源

Emerging evidence suggests that endothelial dysfunction may play a role in severe COVID-19 in both adults and children, as well as in cases of long COVID-19, indicating shared pathophysiological pathways. This narrative review provides a comprehensive summary of the current knowledge on endothelial dysfunction caused by COVID-19, including new insights into long COVID-19 and pediatric cases. Understanding these aspects is crucial not only for comprehending the multi-systemic impact of COVID-19, but also for enhancing patient care and outcomes.
Objectives: To review current literature on the role of endothelial dysfunction in coronavirus disease-2019 (COVID-19) infection in terms of pathophysiology, laboratory features and markers, clinical phenotype in adults and children, as well as long COVID-19. Content: We conducted a thorough assessment of the literature and critically analyzed current data, mostly utilizing the PubMed and Medline search engines to find original studies published in the previous decade. Summary and Outlook: Accumulating evidence suggests that endothelial dysfunction may be a common denominator of severe COVID-19 in adults and children, as well as long COVID-19, implicating mutual pathophysiological pathways. This narrative review summarizes the up-to-date knowledge of endothelial dysfunction caused by COVID-19, including novel aspects of long COVID-19 and pediatric disease. This knowledge is important in order not only to understand the multisystemic attack of COVID-19, but also to improve patient management and prognosis.

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