期刊
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
卷 50, 期 10, 页码 -出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.jogoh.2021.102207
关键词
Male infertility; Spermatogenesis; Genetics
Azoospermia is a common cause of male infertility, and there is currently no accurate non-invasive diagnostic method available. Testis biopsy is necessary to determine the presence of spermatozoa. Studies have shown alterations in microRNA expression in azoospermic patients, which can lead to defects in spermatogenesis.
Azoospermia is a common cause of male infertility without any sperm in the semen and consists of similar to 1% of all males and similar to 15% of infertile ones. Currently, no accurate non-invasive diagnostic method exists for patients with azoospermia and testis biopsy is mandatory to determine if any spermatozoa exist in the testes. Studies have clarified that the expression of some distinct microRNAs shows alterations in azoospermic patients. MicroRNAs play critical roles during spermatogenesis and their dysregulation can defect this process. Here, we review studied microRNAs involved in the pathogenesis of azoospermia and their target genes. Moreover, we will imply the utility of seminal plasma microRNAs as non-invasive diagnostic biomarkers for azoospermia. We hope such studies could help patients with azoospermia in both diagnosis and treatment, in order that they could father their own biological children. (C) 2021 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据