The roles of gold nanoparticles in the detection of amyloid-β peptide for Alzheimer's disease

As the most common form of dementia in humans, Alzheimer's disease (AD) is linked to misfolding and ag-gregation of amyloid-beta (A beta) peptides. Gold nanoparticles (AuNPs) can encapsulate molecules of therapeutic value and enhance transport of drugs through the blood-brain barrier (BBB) in neurodegenerative diseases. AuNPs also have antioxidant effect, anti-amyloidosis effect, unique optical properties and nano-scaled chirality. They have been widely investigated in the diagnosis of AD owing to their excellent properties. Recent years, AuNPs have been the focus on A beta peptides aggregation. However, there is still no comprehensive exposition to explain the roles of AuNPs. Additionally, a series of strategies based on the detection of A beta peptides still need further improvement. Herein, this review aims to explore the roles of AuNPs in the detection of A beta peptides for AD. Furthermore, the review provides more insights for the applications of AuNPs in the sensors for the detection of A beta peptides.

Automated summary

Alzheimer's disease is the most common form of dementia in humans, and it is related to the misfolding and aggregation of Aβ peptides. Gold nanoparticles have excellent properties and can be used in the diagnosis and drug delivery for AD.