期刊
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
卷 45, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colcom.2021.100535
关键词
Hernia repair mesh; Coating; Chitosan; Sodium alginate; Hydrophilicity; Cytocompatibility
资金
- Fundamental Research Funds for the Central Universities [JUSRP22026, JUSRP52013B]
- Priority Academic Program Development of Jiangsu Higher Education Institutions(PAP)
This study successfully improved the biocompatibility of polypropylene mesh by using chitosan and sodium alginate as coatings, promoting cell attachment and proliferation.
Polypropylene (PP) hernia repair mesh has gained much attention due to its low cost, cost-efficiency, stable chemical properties and excellent properties. However, its lack of biocompatibility has greatly limited its clinical application, and different complications such as chronic pain and foreign body reaction are usually found after implantation. Chitosan (CS) and sodium alginate (SA) are among the most exploited naturally derived biomaterials with excellent biocompatibility. Therefore, plasma-treated PP meshes were combined with CS or SA to address these issues in this study. The results demonstrated that the hydrophilicity of the coated meshes exhibited a significant increase. Moreover, the two-component hernia repair meshes created a favorable environment for cell attachment with higher cell proliferation than PP mesh. This work provides insights on the use of naturally biocompatible materials as a potential coating on PP meshes to provide favorable conditions for cell adhesion and growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据