期刊
ASIAN JOURNAL OF PSYCHIATRY
卷 68, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ajp.2021.102964
关键词
Craving; Detoxification; Opioid dependence; Serum Corticotrophin Releasing Factor; Stress
类别
资金
- AIIMS, Delhi under AIIMS Intramural Research Grant [A-549]
The study found significantly higher levels of serum CRF and perceived stress among opioid-dependent subjects compared to non-using controls, with no significant correlation with craving. The significant difference in serum CRF levels suggests the feasibility of measuring CRF levels in peripheral fluids as a biochemical measure of stress.
Corticotrophin Releasing Factor (CRF) might be suitable as biological measure of stress as it is implicated directly in both central neurological and endocrine stress-response. The study aims to compare serum CRF levels and perceived stress in opioid-dependent subjects (n = 53) with non-using controls (n = 47) and to correlate them with general and instantaneous craving (in cases only). Perceived stress score and serum CRF levels were significantly higher among the users. No significant correlation with craving was found. The significant difference in serum CRF levels indicate feasibility of measuring CRF levels in peripheral fluids and asserts its role as biochemical measure of stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据