4.7 Article

Transgenerational Effects of Maternal Immune Activation on Specific Antibody Responses in Layer Chickens

期刊

FRONTIERS IN VETERINARY SCIENCE
卷 9, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2022.832130

关键词

chicken; transgenerational; innate immunity; beta-glucan; lipopolysaccharide; antibody response

资金

  1. Dutch Animal Feed Research Consortium (Vereniging Diervoederonderzoek Nederland)

向作者/读者索取更多资源

Activation of the maternal immune system can impact immune responses in the next generation, which has implications for vaccine efficacy and dietary immune modulation. This study investigates the effects of immune activation in laying hens on specific antibody production in their offspring. The results suggest a transgenerational effect of the maternal immune system on specific antibody response, and imply that maternal immune activation can influence immune modulation and vaccine strategies in the next generation.
Activation of the maternal immune system may affect innate and adaptive immune responses in the next generation and may therefore have implications for vaccine efficacy and dietary immune modulation by feed additives. However, transgenerational effects on immune responses in chickens have been investigated to a limited extend. The present study investigated effects of intratracheal (i.t) specific and aspecific immune activation of laying hens on specific antibody production in the next generation. In two experiments laying hens received intratracheally an immune stimulus with human serum albumin (HuSA) or lipopolysaccharide (LPS). In experiment 1, hatchlings of the immune activated hens were at 4 weeks i.t. immunized with HuSA or HuSA+LPS. Maternal immune activation with LPS increased HuSA specific IgY and IgM responses in offspring. These results suggest a transgenerational effect of the maternal immune system on the specific antibody response in the next generation. In experiment 2 hatchlings received either beta-glucan-enriched feed or control feed and were i.t. immunized with HuSA. Maternal immune activation with LPS decreased IgY anti-HuSA responses after HuSA immunization within hatchlings that received beta-glucan enriched feed. The results of Experiment 2 suggest a transgenerational link between the innate immune system of mother and specific antibody responses in offspring. Despite variabilities in the outcomes of the two experiments, the observations of both suggest a link between the maternal innate immune system and the immune system of the offspring. Furthermore, our results may imply that maternal activation of the innate immune system can influence immune modulating dietary interventions and vaccine strategies in the next generation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据