期刊
FRONTIERS IN VETERINARY SCIENCE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2021.822227
关键词
Aflatoxin B1; turmeric powder; curcumin; oxidative stress; kidney; chicken-broiler; renal damage
资金
- Integrated and innovative key actions for mycotoxin management in the food and feed chain (MycoKey) [678781]
- [H2020-EU.3.2]
Aflatoxin B1 (AFB1) is a human carcinogen that causes hepatotoxicity, immunotoxicity, and kidney damage. Chickens are moderately sensitive to AFB1, leading to reduced growth performance and economic losses. The antioxidant activity of Curcumin (CURC) can help prevent oxidative stress triggered by AFB1 and protect kidney tissue.
Aflatoxin B1 (AFB1) causes hepatotoxicity, immunotoxicity, and kidney damage, and it is included in group I of human carcinogens. The European Commission has established maximum limits of AFB1 in feed, ranging from 5 to 20 mu g/kg. Chicken is moderately sensitive to AFB1, which results in reduced growth performance and economic losses. Oxidative stress triggered by AFB1 plays a crucial role in kidney damage and the antioxidant activity of Curcumin (CURC) could help in preventing such adverse effect. Twenty-days-old broilers were treated for 10 days with AFB1 (0.02 mg/kg feed), alone or in combination with CURC (400 mg/kg feed), to explore the effects on the renal tissue. Animals exposed to AFB1 alone displayed alterations of the oxidative stress parameters compared with controls: serum antioxidant capacity, and enzymatic activity of kidney superoxide dismutase, catalase and glutathione peroxidase were decreased, while renal malondialdehyde levels and NADPH oxidase complex expression were increased. The administration of CURC attenuates all the oxidative stress parameters modified by AFB1 in the chicken kidney, opening new perspectives in the management of aflatoxicosis.
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