期刊
DIVERSITY-BASEL
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/d14020142
关键词
autosome; genetic contribution; mitochondrial DNA; pedigree analysis; sex chromosomes
This study developed a method to calculate the genetic contribution of sex chromosomes and mitochondrial DNA through pedigree analysis. The accuracy of the method was validated through gene-dropping simulations and comparison with genetic contributions. The novel approach provides new insights into the genetic composition of populations and has implications for sustainable breeding and population management.
The genetic contribution with respect to autosomal genes has been widely used to evaluate the genetic diversity of a target population. Here, we developed a method to calculate the genetic contribution with respect to genes on sex chromosomes and mitochondrial DNA through pedigree analysis. To demonstrate the performance, we applied the methods for calculating genetic contributions to example pedigree data. To verify the results of genetic contribution calculations, we performed gene-dropping simulations mimicking flows of genes on autosomes, X and Y chromosomes, and mitochondrial DNA, and then compared the results from the simulation with the corresponding genetic contributions. To investigate the effect of pedigree error, we compared the results of genetic contribution calculations using pedigree data with and without errors. The results of gene-dropping simulation showed good agreement with the results of the genetic contribution calculation. The effect of pedigree errors on the calculation of genetic contribution depended on the error rate. Since the patterns of the genetic contributions of such genes might be different from those on autosomes, the novel approach could provide new information on the genetic composition of populations. The results are expected to contribute to the development of methods for sustainable breeding and population management.
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