COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic

Article Infectious Diseases

Decreased Case Fatality Rate of COVID-19 in the Second Wave: A study in 53 countries or regions

Guihong Fan et al.

Summary: A study found that in 53 countries or regions with the highest COVID-19 death tolls, 43 had lower CFR estimates in the ongoing second wave than in the first wave. This could be due to the effects of social distancing measures.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Review Biochemistry & Molecular Biology

The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

Giovanni Zarrilli et al.

Summary: The histopathologic alterations in COVID-19 patients primarily occur in the lungs and blood vessels, with the highest clinical impact. However, many of the collected morphological data so far are nonspecific, erratic, and possibly associated with other co-existing factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Machine learning-based analysis of alveolar and vascular injury in SARS-CoV-2 acute respiratory failure

Fiorella Calabrese et al.

Summary: This study comprehensively analysed the lungs of 26 patients who died from SARS-CoV-2 acute respiratory failure, revealing predominant vascular injury in the pathological phenotypes, with severe alveolar injury associated with additional superimposed infections and complications. Robust machine learning techniques were used to distinguish these phenotypes and identify potential clinical characteristics at hospital admission that may predict pathological patterns of SARS-CoV-2 infection.

JOURNAL OF PATHOLOGY (2021)

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Letter Infectious Diseases

First and second COVID-19 waves in Japan: A comparison of disease severity and characteristics

Sho Saito et al.

JOURNAL OF INFECTION (2021)

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Article Dermatology

Proven COVID-19-associated pulmonary aspergillosis in patients with severe respiratory failure

Francesco Fortarezza et al.

Summary: The study analyzed histologically diagnosed CAPA in 45 consecutive COVID-19 autopsies and found a 20% incidence of proven CAPA, with most cases occurring in the second wave of the pandemic. The patients were predominantly male with a median age of 74, and a majority were admitted to the intensive care unit.

MYCOSES (2021)

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Article Cell Biology

Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients

Philipp K. Buehler et al.

Summary: Superinfections are common among COVID-19 patients with acute respiratory distress syndrome, leading to lower survival rates, longer intensive care treatment, and reduced ventilator-free days despite the use of empirical antibiotic therapy.

CELL REPORTS MEDICINE (2021)

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Article Pathology