4.6 Article

Cerebrospinal Fluid Levels of AFP and hCG: Validation of the Analytical Method and Application in the Diagnosis of Central Nervous System Germ Cell Tumors

期刊

DIAGNOSTICS
卷 11, 期 11, 页码 -

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MDPI
DOI: 10.3390/diagnostics11111980

关键词

AFP; hCG; cerebrospinal fluid; germ cell tumors; central nervous system tumors

资金

  1. Italian Ministry of Health

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This study evaluated the suitability of an analytical method certified for use on serum and/or amniotic fluid for quantifying hCG and AFP in cerebrospinal fluid. The results showed that the automated immunochemical method can accurately quantify hCG and AFP in CSF for selective and specific diagnosis of secreting germ cell tumors.
The determination of Human Chorionic Gonadotropin (hCG) and Alpha Fetoprotein (AFP) levels on serum and amniotic fluid plays a fundamental role in the diagnosis and follow-up of specific physiological or pathological conditions (e.g., pregnancy, threat of abortion or germ cell tumors). Recently, the quantification of hCG and AFP in other biological fluids has gained great attention to support the diagnosis, prognosis and follow-up of neoplastic diseases deriving from trophoblastic cells, such as germinomas. Most of the commercial kits for hCG and AFP assays are developed to be used on biological fluids such as serum/plasma and/or urine by manufacturing companies. The aim of this work was to evaluate the suitability of the analytical method certified for the use on serum, and/or amniotic fluid for the quantification of hCG and AFP in cerebrospinal fluid, carrying out an internal validation protocol. The data reported here show that the automated immunochemical method is fit for quantification of hCG and AFP in cerebrospinal fluid (CSF), allowing selective and specific diagnosis of secreting germ cell tumors. This is confirmed by the positive correlation between elevated levels of hCG or AFP and the diagnosis of brain tumors.

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