期刊
DIAGNOSTICS
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics11101911
关键词
inflammation; nitro-oxidative stress; endothelial progenitor cells; hematopoietic progenitor cells; physical performance
资金
- European Regional Development Fund under the Innovative Economy Operational Program 2007-2013
- University of Zielona Gora [222267/E-545/S/2019]
Neopterin plays a crucial role in atheromatous process and is related to conventional atherogenic markers; Levels of endothelial progenitor cells are lower in PAD patients and inversely correlated with NPT levels.
Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 +/- 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI <= 0.9 n = 43, ABI <= 0.5 n = 16). A total of 60 subjects aged 70.4 +/- 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 +/- 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI <= 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据