4.6 Article

Diisothiocyanate-Derived Mercapturic Acids Are a Promising Partner for Combination Therapies in Glioblastoma

期刊

ACS OMEGA
卷 7, 期 7, 页码 5929-5936

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c06169

关键词

-

资金

  1. Nazarbayev University Faculty-Development Competitive Research Grants Program [280720FD1907]

向作者/读者索取更多资源

Glioblastoma, the most aggressive tumor of the central nervous system, is difficult to treat due to invasion, chemoresistance, and recurrence. Recent research discovered that diisothiocyanate-derived mercapturic acids from Cruciferae family plants can decrease glioblastoma cell viability. When combined with certain drugs, this combination therapy has an additive or even synergistic effect in restricting cell growth. This strategy holds promise for inhibiting glioblastoma cell growth as a potential therapeutic intervention.
Glioblastoma represents the most aggressive tumor of the central nervous system. Due to invasion of glioblastoma stem cells into the healthy tissue, chemoresistance, and recurrence of the tumor, it is difficult to successfully treat glioblastoma patients, which is demonstrated by the low life expectancy of patients after standard therapy treatment. Recently, we found that diisothiocyanate-derived mercapturic acids, which are isothiocyanate derivatives from plants of the Cruciferae family, provoked a decrease in glioblastoma cell viability. These findings were extended by combining diisothiocyanate-derived mercapturic acids with dinaciclib (a small-molecule inhibitor of cyclin-dependent kinases with anti-proliferative capacity) or temozolomide (TMZ, standard chemotherapeutic agent) to test whether the components have a cytotoxic effect on glioblastoma cells when the dosage is low. Here, we demonstrate that the combination of diisothiocyanate-derived mercapturic acids with dinaciclib or TMZ had an additive or even synergistic effect in the restriction of cell growth dependent on the combination of the components and the glioblastoma cell source. This strategy could be applied to inhibit glioblastoma cell growth as a therapeutic interference of glioblastoma.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据