Electrochemical [4+1] Tandem sp3(C-H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines

3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moi-eties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp(3) (C-H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.

Automated summary

In this study, a one-step electrochemical tandem sp(3)(C-H) double amination was developed for the efficient synthesis of 3-acyl imidazo[1,5-a]pyridines, eliminating the need for the conventional three-step reaction.