期刊
ACS OMEGA
卷 6, 期 40, 页码 26428-26438出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c03679
关键词
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资金
- University of Roma La Sapienza (Progetti di Ricerca Piccoli) [RP118164212B42FE, RM120172A308C63D]
The research indicates that NHPI as a mediator in HAT reactions can modify the selectivity of oxidation reactions, leading to changes in reactivity towards alkylaromatics and alcohols.
A kinetic analysis of the hydrogen atom transfer (HAT) reactions from a series of organic compounds to the iron(IV)-oxo complex [(N4Py)Fe-IV(O)](2+) and to the phthalimide N-oxyl radical (PINO) has been carried out. The results indicate that a higher activating effect of alpha-heteroatoms toward the HAT from C-H bonds is observed with the more electrophilic PINO radical. When the N-hydroxy precursor of PINO, N-hydroxyphthalimide (NHPI), is used as a HAT mediator in the oxidation promoted by [(N4Py)Fe-IV(O)](2+), significant differences in terms of selectivity have been found. Product studies of the competitive oxidations of primary and secondary aliphatic alcohols (1-decanol, cyclopentanol, and cyclohexanol) with alkylaromatics (ethylbenzene and diphenylmethane) demonstrated that it is possible to modify the selectivity of the oxidations promoted by [(N4Py)Fe-IV(O)](2+) in the presence of NHPI. In fact, alkylaromatic substrates are more reactive in the absence of the mediator while alcohols are preferably oxidized in the presence of NHPI.
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