4.6 Article

Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents

期刊

ACS OMEGA
卷 7, 期 7, 页码 5864-5869

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c05888

关键词

-

资金

  1. HEC Pharm Group in Dongguan City, Guangdong, China - Science and Technology Development Fund, Macau SAR [0030/2018/A1]

向作者/读者索取更多资源

Boron nanoparticles with hydroxyl groups were synthesized in situ and characterized using various analytical techniques. These nanoparticles exhibited good antimalarial activity against Plasmodium falciparum, while showing low toxicity to various cell lines.
Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (Bm(OH)n), were characterized using H-1 and B-11 NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC50 value of 0.0021 mu M and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据