期刊
ACS OMEGA
卷 7, 期 7, 页码 5864-5869出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c05888
关键词
-
资金
- HEC Pharm Group in Dongguan City, Guangdong, China - Science and Technology Development Fund, Macau SAR [0030/2018/A1]
Boron nanoparticles with hydroxyl groups were synthesized in situ and characterized using various analytical techniques. These nanoparticles exhibited good antimalarial activity against Plasmodium falciparum, while showing low toxicity to various cell lines.
Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (Bm(OH)n), were characterized using H-1 and B-11 NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC50 value of 0.0021 mu M and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.
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